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dc.contributor.authorBrazier, Jon
dc.contributor.authorAntrobus, M
dc.contributor.authorStebbings, G
dc.contributor.authorDay, S
dc.contributor.authorHeffernan, S
dc.contributor.authorCross, M
dc.contributor.authorWilliams, A
dc.date.accessioned2019-06-21T00:06:41Z
dc.date.available2019-06-21T00:06:41Z
dc.date.issued2019-06-04
dc.identifier.citationBrazier , J , Antrobus , M , Stebbings , G , Day , S , Heffernan , S , Cross , M & Williams , A 2019 , ' Tendon and Ligament Injuries in Elite Rugby: The Potential Genetic Influence ' , Sports , vol. 7 , no. 6 , 138 . https://doi.org/10.3390/sports7060138
dc.identifier.otherPURE: 16894854
dc.identifier.otherPURE UUID: e30c846e-7b70-4894-90e7-f054d8dd4adf
dc.identifier.urihttp://hdl.handle.net/2299/21384
dc.description.abstractThis article reviews tendon and ligament injury incidence and severity within elite rugby union and rugby league. Furthermore, it discusses the biological makeup of tendons and ligaments and how genetic variation may influence this and predisposition to injury. Elite rugby has one of the highest reported injury incidences of any professional sport. This is likely due to a combination of well-established injury surveillance systems and the characteristics of the game, whereby high-impact body contact frequently occurs, in addition to the high intensity, multispeed and multidirectional nature of play. Some of the most severe of all these injuries are tendon and ligament/joint (non-bone), and therefore, potentially the most debilitating to a player and playing squad across a season or World Cup competition. The aetiology of these injuries is highly multi-factorial, with a growing body of evidence suggesting that some of the inter-individual variability in injury susceptibility may be due to genetic variation. However, little effort has been devoted to the study of genetic injury traits within rugby athletes. Due to a growing understanding of the molecular characteristics underpinning the aetiology of injury, investigating genetic variation within elite rugby is a viable and worthy proposition. Therefore, we propose several single nucleotide polymorphisms within candidate genes of interest; COL1A1, COL3A1, COL5A1, MIR608, MMP3, TIMP2, VEGFA, NID1 and COLGALT1 warrant further study within elite rugby and other invasion sports.en
dc.format.extent27
dc.language.isoeng
dc.relation.ispartofSports
dc.rightsOpen
dc.subjectgenomics; rugby; polymorphisms; soft-tissue injury; tendinopathy; ligament rupture
dc.titleTendon and Ligament Injuries in Elite Rugby: The Potential Genetic Influenceen
dc.contributor.institutionDepartment of Psychology and Sports Sciences
dc.contributor.institutionCentre for Research in Psychology and Sport Sciences
dc.contributor.institutionSport, Health and Exercise
dc.contributor.institutionSchool of Life and Medical Sciences
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2019-06-04
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.3390/sports7060138
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.typeOther
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


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