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dc.contributor.authorAlhayali, Amani
dc.contributor.authorVuddanda, Parameswara
dc.contributor.authorVelagaa, Sitaram
dc.date.accessioned2019-06-26T00:05:51Z
dc.date.available2019-06-26T00:05:51Z
dc.date.issued2019-10-01
dc.identifier.citationAlhayali , A , Vuddanda , P & Velagaa , S 2019 , ' Silodosin oral films: Development, physico-mechanical properties and in vitro dissolution studies in simulated saliva ' , Journal of Drug Delivery Science and Technology , vol. 53 , 101122 . https://doi.org/10.1016/j.jddst.2019.06.019
dc.identifier.issn1773-2247
dc.identifier.otherPURE: 17003713
dc.identifier.otherPURE UUID: c8c48503-a843-48f5-8da2-3d25a677c8c6
dc.identifier.otherScopus: 85068383704
dc.identifier.otherORCID: /0000-0003-2645-5719/work/62751175
dc.identifier.urihttp://hdl.handle.net/2299/21391
dc.description.abstractSublingual film dosage forms for drugs used for fast symptomatic treatment have promise because they allow a rapid onset of action. The aim of this study was to prepare films of silodosin intended for sublingual administration for the symptomatic treatment of benign prostatic hyperplasia in men. Hydroxypropyl methylcellulose (HPMC) or hydroxypropyl methylcellulose acetate succinate (HPMC-AS) were used as film-forming polymers. The effects of the polymers and the surfactant tocopherol polyethylene glycol succinate (TPGS) on the physico-mechanical properties and dissolution behavior of the films in simulated saliva were investigated. The eight silodosin oral films developed (F1–F8) contained 8 mg silodosin per 6 cm2 film and HPMC or HPMC-AS in drug:polymer ratios of 1:5 or 1:3, while four also contained TPGS (0.5% w/w). The films were characterized using DSC, TGA, SEM, and PXRD and the mechanical properties were investigated by measuring tensile strength, elongation at break and Young's modulus. The mechanical properties of the films were dependent on the ratio of polymer used. The in vitro dissolution and drug release studies indicated that HPMC-AS films disintegrated more quickly than HPMC films. Silodosin was shown to be dispersed within the polymers. Despite silodosin being submicronized in the HPMC films, the dissolution and drug release rate (time for 80% release) from HPMC films was significantly faster than from HPMC-AS films. TPGS increased the drug release rate to a greater extent with HPMC than with HPMC-AS. The degree of saturation of formulation F4 was >1, which shows potential for improving oral absorption of silodosin.en
dc.format.extent40
dc.language.isoeng
dc.relation.ispartofJournal of Drug Delivery Science and Technology
dc.rightsOpen
dc.subjectHPMC
dc.subjectHPMC-AS
dc.subjectSilodosin
dc.subjectSimulated saliva
dc.subjectSublingual oral films
dc.subjectTPGS
dc.subjectPharmaceutical Science
dc.titleSilodosin oral films: Development, physico-mechanical properties and in vitro dissolution studies in simulated salivaen
dc.contributor.institutionDepartment of Clinical and Pharmaceutical Sciences
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionSchool of Life and Medical Sciences
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85068383704&partnerID=8YFLogxK
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Accepted Version
dcterms.dateAccepted2019-10-01
rioxxterms.versionAM
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.jddst.2019.06.019
rioxxterms.licenseref.uriOther
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


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