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dc.contributor.authorVasdev, N.
dc.contributor.authorZargar, H.
dc.contributor.authorNoël, J. P.
dc.contributor.authorVeeratterapillay, R.
dc.contributor.authorFairey, A. S.
dc.contributor.authorMertens, L. S.
dc.contributor.authorDinney, C. P.
dc.contributor.authorMir, M. C.
dc.contributor.authorKrabbe, L. M.
dc.contributor.authorCookson, M. S.
dc.contributor.authorJacobsen, N. E.
dc.contributor.authorGandhi, N. M.
dc.contributor.authorGriffin, J.
dc.contributor.authorMontgomery, J. S.
dc.contributor.authorYu, E. Y.
dc.contributor.authorXylinas, E.
dc.contributor.authorCampain, N. J.
dc.contributor.authorKassouf, W.
dc.contributor.authorDall’Era, M. A.
dc.contributor.authorSeah, J. A.
dc.contributor.authorErcole, C. E.
dc.contributor.authorHorenblas, S.
dc.contributor.authorSridhar, S. S.
dc.contributor.authorMcGrath, J. S.
dc.contributor.authorAning, J.
dc.contributor.authorShariat, S. F.
dc.contributor.authorWright, J. L.
dc.contributor.authorMorgan, T. M.
dc.contributor.authorBivalacqua, T. J.
dc.contributor.authorNorth, S.
dc.contributor.authorBarocas, D. A.
dc.contributor.authorLotan, Y.
dc.contributor.authorGrivas, P.
dc.contributor.authorStephenson, A. J.
dc.contributor.authorShah, J. B.
dc.contributor.authorvan Rhijn, B. W.
dc.contributor.authorDaneshmand, S.
dc.contributor.authorSpiess, P. E.
dc.contributor.authorHolzbeierlein, J. M.
dc.contributor.authorThorpe, A.
dc.contributor.authorBlack, P. C.
dc.date.accessioned2019-07-17T11:53:21Z
dc.date.available2019-07-17T11:53:21Z
dc.date.issued2019-01-23
dc.identifier.citationVasdev , N , Zargar , H , Noël , J P , Veeratterapillay , R , Fairey , A S , Mertens , L S , Dinney , C P , Mir , M C , Krabbe , L M , Cookson , M S , Jacobsen , N E , Gandhi , N M , Griffin , J , Montgomery , J S , Yu , E Y , Xylinas , E , Campain , N J , Kassouf , W , Dall’Era , M A , Seah , J A , Ercole , C E , Horenblas , S , Sridhar , S S , McGrath , J S , Aning , J , Shariat , S F , Wright , J L , Morgan , T M , Bivalacqua , T J , North , S , Barocas , D A , Lotan , Y , Grivas , P , Stephenson , A J , Shah , J B , van Rhijn , B W , Daneshmand , S , Spiess , P E , Holzbeierlein , J M , Thorpe , A & Black , P C 2019 , ' Concomitant CIS on TURBT does not impact oncological outcomes in patients treated with neoadjuvant or induction chemotherapy followed by radical cystectomy ' , World Journal of Urology , vol. 37 , no. 1 , pp. 165-172 . https://doi.org/10.1007/s00345-018-2361-0
dc.identifier.issn0724-4983
dc.identifier.otherPURE: 16662879
dc.identifier.otherPURE UUID: 4d35e8b4-3ae5-48e8-b70e-435d9cbefde9
dc.identifier.otherScopus: 85048075423
dc.identifier.otherPubMed: 29882105
dc.identifier.urihttp://hdl.handle.net/2299/21447
dc.description© Springer-Verlag GmbH Germany, part of Springer Nature 2018
dc.description.abstractBackground: Cisplatin-based neoadjuvant chemotherapy (NAC) for muscle invasive bladder cancer improves all-cause and cancer specific survival. We aimed to evaluate whether the detection of carcinoma in situ (CIS) at the time of initial transurethral resection of bladder tumor (TURBT) has an oncological impact on the response to NAC prior to radical cystectomy. Patients and methods: Patients were identified retrospectively from 19 centers who received at least three cycles of NAC or induction chemotherapy for cT2-T4aN0-3M0 urothelial carcinoma of the bladder followed by radical cystectomy between 2000 and 2013. The primary and secondary outcomes were pathological response and overall survival, respectively. Multivariable analysis was performed to determine the independent predictive value of CIS on these outcomes. Results: Of 1213 patients included in the analysis, 21.8% had concomitant CIS. Baseline clinical and pathologic characteristics of the ‘CIS’ versus ‘no-CIS’ groups were similar. The pathological response did not differ between the two arms when response was defined as pT0N0 (17.9% with CIS vs 21.9% without CIS; p = 0.16) which may indicate that patients with CIS may be less sensitive to NAC or ≤ pT1N0 (42.8% with CIS vs 37.8% without CIS; p = 0.15). On Cox regression model for overall survival for the cN0 cohort, the presence of CIS was not associated with survival (HR 0.86 (95% CI 0.63–1.18; p = 0.35). The presence of LVI (HR 1.41, 95% CI 1.01–1.96; p = 0.04), hydronephrosis (HR 1.63, 95% CI 1.23–2.16; p = 0.001) and use of chemotherapy other than ddMVAC (HR 0.57, 95% CI 0.34–0.94; p = 0.03) were associated with shorter overall survival. For the whole cohort, the presence of CIS was also not associated with survival (HR 1.05 (95% CI 0.82–1.35; p = 0.70). Conclusion: In this multicenter, real-world cohort, CIS status at TURBT did not affect pathologic response to neoadjuvant or induction chemotherapy. This study is limited by its retrospective nature as well as variability in chemotherapy regimens and surveillance regimens.en
dc.format.extent8
dc.language.isoeng
dc.relation.ispartofWorld Journal of Urology
dc.subjectAged
dc.subjectAntineoplastic Agents/therapeutic use
dc.subjectCarcinoma in Situ/mortality
dc.subjectCisplatin/therapeutic use
dc.subjectCystectomy
dc.subjectFemale
dc.subjectHumans
dc.subjectInduction Chemotherapy
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNeoadjuvant Therapy
dc.subjectRetrospective Studies
dc.subjectSurvival Rate
dc.subjectTreatment Outcome
dc.subjectUrinary Bladder Neoplasms/mortality
dc.titleConcomitant CIS on TURBT does not impact oncological outcomes in patients treated with neoadjuvant or induction chemotherapy followed by radical cystectomyen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy, Pharmacology and Postgraduate Medicine
dc.description.statusPeer reviewed
dc.date.embargoedUntil2019-06-07
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85048075423&partnerID=8YFLogxK
rioxxterms.versionAM
rioxxterms.versionofrecordhttps://doi.org/10.1007/s00345-018-2361-0
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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