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        Method of coating particles

        Author
        School of Life and Medical Sciences
        Department of Clinical and Pharmaceutical Sciences
        Centre for Research into Topical Drug Delivery and Toxicology
        Pharmaceutics
        Pharmaceutical Analysis and Product Characterisation
        Bioadhesive Drug Delivery Group
        Liu, Fang
        Attention
        2299/21458
        Abstract
        The invention relates to methods for coating particles characterised by the addition of a powdered excipient, typically during coating. Typically, the coating method comprises Wurster fluidised bed coating. The invention provides a method for coating particles in a coater comprising a coating processing chamber, wherein the particles comprise an active pharmaceutical ingredient, the method comprising: (i) adding particles to the processing chamber; (ii) adding a coating formulation to the processing chamber through a first inlet; and (iii) adding a powdered excipient to the processing chamber through a second inlet. The invention further provides coated particles obtainable by the method of the invention, preferably where at least 80% w/w of the coated particles have a particle size range of I 0-1200-tm. The coated particles are preferably for use in a method of adruinistering an active pharmaceutical ingredient or for use in a method of treating or preventing a disease or condition. The invention further provides a pharmaceutical composition
        Publication date
        2019-04
        Other links
        http://hdl.handle.net/2299/21458
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