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dc.contributor.authorBiria, Marjan
dc.contributor.authorHuang, Fiona-Xiaofei
dc.contributor.authorWorbe, Yulia
dc.contributor.authorFineberg, Naomi
dc.contributor.authorRobbins, Trevor W.
dc.contributor.authorFernandez-Egea, Emilio
dc.date.accessioned2019-07-29T11:01:25Z
dc.date.available2019-07-29T11:01:25Z
dc.date.issued2019-08-01
dc.identifier.citationBiria , M , Huang , F-X , Worbe , Y , Fineberg , N , Robbins , T W & Fernandez-Egea , E 2019 , ' A cross sectional study of impact and clinical risk factors of antipsychotic-induced OCD ' , European Neuropsychopharmacology , vol. 29 , no. 8 , pp. 905-913 . https://doi.org/10.1016/j.euroneuro.2019.06.006
dc.identifier.issn0924-977X
dc.identifier.otherPURE: 16945885
dc.identifier.otherPURE UUID: 11eb1cf2-8774-4751-bf81-ee0d98f1937e
dc.identifier.otherScopus: 85068574743
dc.identifier.urihttp://hdl.handle.net/2299/21480
dc.descriptionCopyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.
dc.description.abstractA large proportion of schizophrenia patients treated with second generation antipsychotics will develop Obsessive Compulsive Disorder (OCD). However, there are few studies about the impact of this comorbidity and who is at higher risk. In this study of clozapine-treated patients, we aimed to determine the impact on outcome of clozapine-induced OCD, as well as the clinical and sociodemographic risk factors related to OCD-onset in clozapine patients. We had strict and novel inclusion criteria to minimise mis-identification of cases. The Obsessive-Compulsive Inventory-Revised (OCI-R) was used to divide 231 clozapine-treated patients into extreme cases of OCD (OCI ≥ 24 or checking subscale ≥6) versus non-OCD (OCI <15 and checking subscale <4). The Global Assessment of Functioning (GAF), short version of Warwick-Edinburgh Wellbeing scale and Clinical Global Impression for schizophrenia (CGI) scales were used to determine outcome. Socio-demographic information was used to identify the risk factors for OCD development. We found that schizophrenia patients with OCD symptoms had a significantly lower patient rated wellbeing scores (p < 0.001) only (no difference in clinician rated wellbeing scores), higher CGI positive (p < 0.01) and higher CGI depressive scores (p < 0.05). The only risk factors that reached significance level were higher treatment dose (p < 0.01) and younger paternal age at birth (p < 0.05). There is scope for future studies based on e.g. imaging and genetic studies to further investigate causality, and in improving clinician screening for OCD.en
dc.format.extent9
dc.language.isoeng
dc.relation.ispartofEuropean Neuropsychopharmacology
dc.rightsOpen
dc.subjectAntipsychotic
dc.subjectClozapine
dc.subjectObsessive compulsive disorder
dc.subjectSchizophrenia
dc.subjectPharmacology
dc.subjectNeurology
dc.subjectClinical Neurology
dc.subjectPsychiatry and Mental health
dc.subjectBiological Psychiatry
dc.subjectPharmacology (medical)
dc.titleA cross sectional study of impact and clinical risk factors of antipsychotic-induced OCDen
dc.contributor.institutionDepartment of Clinical and Pharmaceutical Sciences
dc.contributor.institutionCentre for Health Services and Clinical Research
dc.contributor.institutionSchool of Life and Medical Sciences
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85068574743&partnerID=8YFLogxK
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2019-08-01
rioxxterms.versionAM
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.euroneuro.2019.06.006
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


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