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dc.contributor.authorCook, Michael
dc.contributor.authorAbou Shamat, Mohamad
dc.date.accessioned2019-07-29T14:42:31Z
dc.date.available2019-07-29T14:42:31Z
dc.date.issued2019-01-05
dc.identifier.citationCook , M & Abou Shamat , M 2019 , ' Soluplus solutions as thermothickening materials for topical drug delivery. ' , Journal of Applied Polymer Science , vol. 136 , no. 1 , 46915 . https://doi.org/10.1002/app.46915
dc.identifier.issn0021-8995
dc.identifier.otherPURE: 15091553
dc.identifier.otherPURE UUID: d6a4edf5-a52a-4cb6-8f01-6d8b914df22b
dc.identifier.otherScopus: 85053435361
dc.identifier.urihttp://hdl.handle.net/2299/21492
dc.description.abstractSoluplus is a pharmaceutical excipient used primarily in the manufacture of solid dispersions. The polymer also exhibits interesting rheology in aqueous solution, increasing in viscosity as the solution is warmed. This material could have application topical drug delivery to sites including the skin, vagina, rectum or nasal mucosa, where the increase in viscosity allows for improved retention. However, there exists very little information surrounding this “thermothickening” phenomenon and the effect of solution composition on temperature-dependent rheology. In this study, the effect of soluplus concentration, salt inclusion, ethanol addition, and pH on temperature-dependent rheology was measured. The rheology of the solutions was unaffected by pH over the range tolerated by the skin (pH 4–7), but the inclusion of ethanol rapidly negated the thermothickening effect. “Salting out” of the solutions resulted in a depression of gelation temperatures, and an increase in both storage and loss moduli of the solutions. 30% (w/v) soluplus in 1 M NaCl or KCl was identified as a potential thermothickening agent for topical drug delivery.en
dc.language.isoeng
dc.relation.ispartofJournal of Applied Polymer Science
dc.subjectmucoadhesion
dc.subjectmucosal drug delivery
dc.subjectpoly(N-vinylcaprolactam)
dc.subjectthermogelling
dc.subjectthermoresponsive
dc.subjectChemistry(all)
dc.subjectSurfaces, Coatings and Films
dc.subjectPolymers and Plastics
dc.subjectMaterials Chemistry
dc.titleSoluplus solutions as thermothickening materials for topical drug delivery.en
dc.contributor.institutionDepartment of Pharmacy, Pharmacology and Postgraduate Medicine
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Clinical and Pharmaceutical Sciences
dc.description.statusPeer reviewed
dc.date.embargoedUntil2019-09-12
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85053435361&partnerID=8YFLogxK
rioxxterms.versionAM
rioxxterms.versionofrecordhttps://doi.org/10.1002/app.46915
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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