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        Lifetime Bipolar Disorder comorbidity and related clinical characteristics in patients with primary Obsessive Compulsive Disorder: a report from the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS)

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        Review_submitted_19_Apr_19_Manuscript_Dell_Osso_ICOCS_BD_OCD_WITHOUT_track_changes.pdf (PDF, 181Kb)
        Author
        Dell'Osso, Bernado
        Vismara, Matteo
        Benatti, Beatrice
        Cirnigliaro, Giovanna
        Grancini, Benedetta
        Fineberg, Naomi
        Van Ameringen, Michael
        Hollander, Eric
        Stein, Dan J.
        Menchon, Josè M
        Rodriguez, Carolyn I
        Nicolini, Humberto
        Lanzagorta, Nuria
        Pallanti, Stefano
        Grassi, Giacomo
        Lochner, Christine
        Marazziti, Donatella
        Hranov, Georgi
        Karamustafalioglu, Oguz
        Hranov, Luchezar
        Zohar, Joseph
        Attention
        2299/21549
        Abstract
        IntroductionBipolar disorder (BD) and obsessive compulsive disorder (OCD) are prevalent, comorbid, and disabling conditions, often characterized by early onset and chronic course. When comorbid, OCD and BD can determine a more pernicious course of illness, posing therapeutic challenges for clinicians. Available reports on prevalence and clinical characteristics of comorbidity between BD and OCD showed mixed results, likely depending on the primary diagnosis of analyzed samples.MethodsWe assessed prevalence and clinical characteristics of BD comorbidity in a large international sample of patients with primary OCD (n = 401), through the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) snapshot database, by comparing OCD subjects with vs without BD comorbidity.ResultsAmong primary OCD patients, 6.2% showed comorbidity with BD. OCD patients with vs without BD comorbidity more frequently had a previous hospitalization (p < 0.001) and current augmentation therapies (p < 0.001). They also showed greater severity of OCD (p < 0.001), as measured by the Yale-Brown Obsessive Compulsive Scale (Y-BOCS).ConclusionThese findings from a large international sample indicate that approximately 1 out of 16 patients with primary OCD may additionally have BD comorbidity along with other specific clinical characteristics, including more frequent previous hospitalizations, more complex therapeutic regimens, and a greater severity of OCD. Prospective international studies are needed to confirm our findings.
        Publication date
        2019-05-27
        Published in
        CNS Spectrums
        Published version
        https://doi.org/10.1017/S1092852919001068
        Other links
        http://hdl.handle.net/2299/21549
        Metadata
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