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dc.contributor.authorAdatia, Krishma
dc.contributor.authorFarag, Mohamed
dc.contributor.authorGue, Ying X.
dc.contributor.authorSrinivasan, Manivannan
dc.contributor.authorGorog, Diana
dc.date.accessioned2019-08-07T01:37:17Z
dc.date.available2019-08-07T01:37:17Z
dc.date.issued2019-10-30
dc.identifier.citationAdatia , K , Farag , M , Gue , Y X , Srinivasan , M & Gorog , D 2019 , ' Relationship of platelet reactivity and inflammatory markers to recurrent adverse events in patients with ST-elevation myocardial infarction ' , Thrombosis and haemostasis , vol. 119 , no. 11 , pp. 1785-1794 . https://doi.org/10.1055/s-0039-1695007
dc.identifier.issn0340-6245
dc.identifier.otherPURE: 17107784
dc.identifier.otherPURE UUID: 227405f7-3546-4a13-beba-f8efd1ee3746
dc.identifier.otherScopus: 85074308710
dc.identifier.urihttp://hdl.handle.net/2299/21558
dc.description© 2019 Thieme Publishing Group. This is an accepted manuscript of an article accepted for publication in Thrombosis and Haemostasis: https://dx.doi.org/10.1055/s-0039-1695007
dc.description.abstractBackground Patients with ST-elevation myocardial infarction (STEMI) exhibit pro-thrombotic and pro-inflammatory states. Markers of enhanced platelet reactivity and inflammation are predictive of adverse outcome. However, the relationship between these biomarkers, and their combined usefulness for risk stratification, is not clear. Methods ?In a prospective study of 541 patients presenting with STEMI, blood samples were taken on arrival to measure high-sensitivity C-reactive protein (hs-CRP), neutrophil/lymphocyte ratio (NLR) and platelet reactivity using the point-of-care Global Thrombosis Test. These biomarkers, alone and in combination, were related to the occurrence of major adverse cardiovascular events (MACE, defined as composite of cardiovascular death, myocardial infarction and cerebrovascular accident) at 30 days and 12 months. Results ?Platelet reactivity and hs-CRP, but not NLR, were weakly predictive of MACE at 30 days and 12 months. The combination of enhanced platelet reactivity and raised hs-CRP was strongly predictive of MACE at 30 days (hazard ratio [HR] 3.46 [95% confidence interval [CI] 1.81-6.62], p < 0.001) and 12 months (HR 3.46 [95% CI 1.81-6.63], p < 0.001). Combination of all three biomarkers (NLR, hs-CRP and platelet reactivity) provided the best prediction of MACE at 30 days (HR 3.73 [95% CI 1.69-8.27], p < 0.001) and 12 months (HR 3.85 [95% CI 1.72-8.60], p < 0.001), and improved the prediction of MACE when added to Thrombolysis In Myocardial Infarction score (net reclassification index 0.296, p < 0.001). Conclusion ?A combination of three easy to measure biomarkers on arrival, namely hs-CRP, NLR and platelet reactivity, can help identify STEMI patients at high risk of recurrent adverse events over the subsequent year.en
dc.format.extent10
dc.language.isoeng
dc.relation.ispartofThrombosis and haemostasis
dc.subjectSTEMI
dc.subjectinflammation
dc.subjectlymphocyte
dc.subjectneutrophil
dc.subjectplatelet reactivity
dc.subjectHematology
dc.titleRelationship of platelet reactivity and inflammatory markers to recurrent adverse events in patients with ST-elevation myocardial infarctionen
dc.contributor.institutionDepartment of Clinical and Pharmaceutical Sciences
dc.contributor.institutionCentre for Health Services and Clinical Research
dc.contributor.institutionBasic and Clinical Science Unit
dc.contributor.institutionSchool of Life and Medical Sciences
dc.description.statusPeer reviewed
dc.date.embargoedUntil2020-08-22
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85074308710&partnerID=8YFLogxK
rioxxterms.versionAM
rioxxterms.versionofrecordhttps://doi.org/10.1055/s-0039-1695007
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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