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dc.contributor.authorBhutto, Zohaib Ahmed
dc.contributor.authorHe, Fang
dc.contributor.authorZloh, Mire
dc.contributor.authorYang, Jing
dc.contributor.authorHuang, Jinhu
dc.contributor.authorGuo, Tingting
dc.contributor.authorWang, Liping
dc.date.accessioned2019-08-20T12:31:12Z
dc.date.available2019-08-20T12:31:12Z
dc.date.issued2018-03-13
dc.identifier.citationBhutto , Z A , He , F , Zloh , M , Yang , J , Huang , J , Guo , T & Wang , L 2018 , ' Use of quercetin in animal feed : effects on the P-gp expression and pharmacokinetics of orally administrated enrofloxacin in chicken ' , Scientific Reports , vol. 8 , no. 1 , 4400 . https://doi.org/10.1038/s41598-018-22354-1
dc.identifier.issn2045-2322
dc.identifier.otherPURE: 13665017
dc.identifier.otherPURE UUID: 930c223a-72ac-457a-a245-bf030aac5484
dc.identifier.otherPubMed: 29535328
dc.identifier.otherPubMedCentral: PMC5849680
dc.identifier.otherScopus: 85044151766
dc.identifier.urihttp://hdl.handle.net/2299/21603
dc.description.abstractModulation of P-glycoprotein (P-gp, encoded by Mdr1) by xenobiotics plays central role in pharmacokinetics of various drugs. Quercetin has a potential to modulate P-gp in rodents, however, its effects on P-gp modulation in chicken are still unclear. Herein, study reports role of quercetin in modulation of P-gp expression and subsequent effects on the pharmacokinetics of enrofloxacin in broilers. Results show that P-gp expression was increased in a dose-dependent manner following exposure to quercetin in Caco-2 cells and tissues of chicken. Absorption rate constant and apparent permeability coefficient of rhodamine 123 were decreased, reflecting efflux function of P-gp in chicken intestine increased by quercetin. Quercetin altered pharmacokinetic of enrofloxacin by decreasing area under curve, peak concentration, and time to reach peak concentration and by increasing clearance rate. Molecular docking shows quercetin can form favorable interactions with binding pocket of chicken xenobiotic receptor (CXR). Results provide convincing evidence that quercetin induced P-gp expression in tissues by possible interaction with CXR, and consequently reducing bioavailability of orally administered enrofloxacin through restricting its intestinal absorption and liver/kidney clearance in broilers. The results can be further extended to guide reasonable use of quercetin to avoid drug-feed interaction occurred with co-administered enrofloxacin or other similar antimicrobials.en
dc.format.extent12
dc.language.isoeng
dc.relation.ispartofScientific Reports
dc.rightsOpen
dc.subjectJournal Article
dc.titleUse of quercetin in animal feed : effects on the P-gp expression and pharmacokinetics of orally administrated enrofloxacin in chickenen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85044151766&partnerID=8YFLogxK
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2018-03-13
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1038/s41598-018-22354-1
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


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