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dc.contributor.authorSwainson, Sadie M.E.
dc.contributor.authorStyliari, Ioanna Danai
dc.contributor.authorTaresco, Vincenzo
dc.contributor.authorGarnett, Martin C.
dc.date.accessioned2019-09-28T00:07:15Z
dc.date.available2019-09-28T00:07:15Z
dc.date.issued2019-09-25
dc.identifier.citationSwainson , S M E , Styliari , I D , Taresco , V & Garnett , M C 2019 , ' Poly (glycerol adipate) (PGA), an enzymatically synthesized functionalizable polyester and versatile drug delivery carrier : A literature update ' , Polymers , vol. 11 , no. 10 , 1561 , pp. 1-11 . https://doi.org/10.3390/polym11101561
dc.identifier.issn2073-4360
dc.identifier.otherPURE: 17365053
dc.identifier.otherPURE UUID: 3ebee760-7839-4682-938e-90e7b665d402
dc.identifier.otherORCID: /0000-0002-7476-2994/work/62751562
dc.identifier.otherScopus: 85073365697
dc.identifier.urihttp://hdl.handle.net/2299/21704
dc.description.abstractThe enzymatically synthesized poly (glycerol adipate) (PGA) has demonstrated all the desirable key properties required from a performing biomaterial to be considered a versatile "polymeric-tool" in the broad field of drug delivery. The step-growth polymerization pathway catalyzed by lipase generates a highly functionalizable platform while avoiding tedious steps of protection and deprotection. Synthesis requires only minor purification steps and uses cheap and readily available reagents. The final polymeric material is biodegradable, biocompatible and intrinsically amphiphilic, with a good propensity to self-assemble into nanoparticles (NPs). The free hydroxyl group lends itself to a variety of chemical derivatizations via simple reaction pathways which alter its physico-chemical properties with a possibility to generate an endless number of possible active macromolecules. The present work aims to summarize the available literature about PGA synthesis, architecture alterations, chemical modifications and its application in drug and gene delivery as a versatile carrier. Following on from this, the evolution of the concept of enzymatically-degradable PGA-drug conjugation has been explored, reporting recent examples in the literature.en
dc.format.extent11
dc.language.isoeng
dc.relation.ispartofPolymers
dc.rightsOpen
dc.subjectPoly(glycerol adipate)
dc.subjectfunctionalization
dc.subjectpolymeric platforms
dc.subjectbiodegradable
dc.subjectlipase
dc.subjectBiodegradable
dc.subjectFunctionalization
dc.subjectPolymeric platforms
dc.subjectLipase
dc.subjectChemistry(all)
dc.subjectPolymers and Plastics
dc.titlePoly (glycerol adipate) (PGA), an enzymatically synthesized functionalizable polyester and versatile drug delivery carrier : A literature updateen
dc.contributor.institutionDepartment of Clinical and Pharmaceutical Sciences
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85073365697&partnerID=8YFLogxK
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2019-09-25
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.3390/polym11101561
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.typeOther
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


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