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dc.contributor.authorHoffman, Ewelina A
dc.contributor.authorGizelska, Katarzyna
dc.contributor.authorMirowski, Marek
dc.contributor.authorMielicki, Wojciech
dc.date.accessioned2019-10-23T00:08:06Z
dc.date.available2019-10-23T00:08:06Z
dc.date.issued2015-05-13
dc.identifier.citationHoffman , E A , Gizelska , K , Mirowski , M & Mielicki , W 2015 , ' Arsenic trioxide downregulates cancer procoagulant activity in MCF-7 and WM-115 cell lines in vitro ' , Contemporary Oncology (Poznan, Poland) , vol. 19 , no. 2 , pp. 108-12 . https://doi.org/10.5114/wo.2014.41390
dc.identifier.issn1428-2526
dc.identifier.otherPURE: 11419839
dc.identifier.otherPURE UUID: e86d09ea-2af8-4936-b62a-87a98368a739
dc.identifier.otherPubMed: 26034387
dc.identifier.otherPubMedCentral: PMC4444438
dc.identifier.otherScopus: 84929417012
dc.identifier.otherORCID: /0000-0002-7998-924X/work/63687349
dc.identifier.urihttp://hdl.handle.net/2299/21788
dc.description© 2015 Termedia Sp. z o. o. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
dc.description.abstractTHE AIM OF THE STUDY: To analyze human breast cancer cell line MCF-7 and human malignant melanoma cell line WM-115 in order to characterize the cellular expression of CP and to evaluate whether ATO may affect this activity, as well as the viability of the cells.MATERIAL AND METHODS: The inhibitory effect of arsenic trioxide on the proliferation of MCF-7 and WM-115 cells were measured with MTT test. The activity of cancer procoagulant after ATO exposure was determined by a specific three-stage chromogenic assay.RESULTS: ATO decreased the CP activity in a dose- and time-dependent manner in MCF-7 cells with no effect on cell proliferation at the same time. However, it affected the CP activity of WM-115 cells in a different way. Reduction in CP activity was followed by an increase after 48 h incubation. The cells viability results showed dose-and time-correlated response within high arsenic concentrations.CONCLUSIONS: Arsenic trioxide downregulates the CP expression in human breast cancer and melanoma cells.en
dc.format.extent5
dc.language.isoeng
dc.relation.ispartofContemporary Oncology (Poznan, Poland)
dc.rightsOpen
dc.subjectJournal Article
dc.titleArsenic trioxide downregulates cancer procoagulant activity in MCF-7 and WM-115 cell lines in vitroen
dc.contributor.institutionDepartment of Pharmacy, Pharmacology and Postgraduate Medicine
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2015-05-13
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.5114/wo.2014.41390
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


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