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dc.contributor.authorMohylyuk, Valentyn
dc.contributor.authorStyliari, Ioanna Danai
dc.contributor.authorNovykov, Dmytryi
dc.contributor.authorPikett, Reiss
dc.contributor.authorDattani, Rajeev
dc.date.accessioned2019-10-26T00:09:22Z
dc.date.available2019-10-26T00:09:22Z
dc.date.issued2019-12
dc.identifier.citationMohylyuk , V , Styliari , I D , Novykov , D , Pikett , R & Dattani , R 2019 , ' Assessment of the effect of Cellets’ particle size on the flow in a Wurster fluid-bed coater via powder rheology ' , Journal of Drug Delivery Science and Technology , vol. 54 , 101320 . https://doi.org/10.1016/j.jddst.2019.101320
dc.identifier.issn1773-2247
dc.identifier.otherPURE: 17515292
dc.identifier.otherPURE UUID: 48315c9f-88a4-4532-81e4-b2a77f378ae4
dc.identifier.otherScopus: 85073152862
dc.identifier.otherORCID: /0000-0002-7476-2994/work/63687442
dc.identifier.urihttp://hdl.handle.net/2299/21800
dc.description© 2019 Elsevier B.V. This manuscript is made available under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International licence (CC BY-NC-ND 4.0). For further details please see: https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.description.abstractThe main objective of this study was to investigate the effect of microcrystalline cellulose (MCC) spheres (Cellets) size effect on the powder properties to assess the possible impact of the Cellets’ size on the powder behaviour in the down-flow bed and horizontal transport zone when a Wurster fluid-bed coater is used. The particle size distribution of Cellets was determined using optical digital microscopy. Standard pharmacopoeia methods as bulk/tapped density and flow rate measured with gravitational funnel method as well as investigation of dynamic angle of repose and dynamic cohesivity index with a rotating drum tester (GranuDrum) and conditioned bulk density, basic flowability energy, specific energy, pressure drop, permeability and compressibility by powder rheometer (FT4 Powder Rheometer®), were employed to characterise the powder's properties of Cellets 90, 100, 200 and 350 (D 50-size from 94 to 424 μm) alone or premixed with 0.5% w/w magnesium stearate. Specific powder rheology methods were proposed for characterisation of Cellets’ behaviour in down-flow bed, the horizontal transport and coating zone. The level of Cellets’ processability decreasing in the Wurster fluid-bed coater with decreasing of Cellets size (D 50) from 425 to 94 μm was established with different powder rheology methods.en
dc.language.isoeng
dc.relation.ispartofJournal of Drug Delivery Science and Technology
dc.subjectCellets
dc.subjectCoating
dc.subjectFlowability
dc.subjectFluid-bed
dc.subjectPellets
dc.subjectPowder rheology
dc.subjectProcessability
dc.subjectPharmaceutical Science
dc.titleAssessment of the effect of Cellets’ particle size on the flow in a Wurster fluid-bed coater via powder rheologyen
dc.contributor.institutionDepartment of Clinical and Pharmaceutical Sciences
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy, Pharmacology and Postgraduate Medicine
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.description.statusPeer reviewed
dc.date.embargoedUntil2020-10-10
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85073152862&partnerID=8YFLogxK
rioxxterms.versionAM
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.jddst.2019.101320
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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