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dc.contributor.authorBraoudaki, Maria
dc.contributor.authorKoutsouris, Dimitrios-Dionysios
dc.contributor.authorKouris, Ioannis
dc.contributor.authorPaidi, Anna
dc.contributor.authorKoutsouri, Georgia
dc.contributor.authorGeorge Lambrou, I
dc.date.accessioned2019-11-08T01:06:48Z
dc.date.available2019-11-08T01:06:48Z
dc.date.issued2018-10-29
dc.identifier.citationBraoudaki , M , Koutsouris , D-D , Kouris , I , Paidi , A , Koutsouri , G & George Lambrou , I 2018 , Bioinformatics and Regression Analyses Manifest Tumor-Specific miRNA Expression Dynamics in Pediatric Embryonal Malignancies . in 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) . IEEE , pp. 5834-5837 , 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) - 2018 , Honolulu , United States , 18/07/18 . https://doi.org/10.1109/EMBC.2018.8513587
dc.identifier.citationconference
dc.identifier.otherPURE: 17661773
dc.identifier.otherPURE UUID: 09c84450-ac0e-4097-83dd-968db5b344d8
dc.identifier.otherPubMed: 30441662
dc.identifier.otherScopus: 85056605692
dc.identifier.urihttp://hdl.handle.net/2299/21853
dc.description.abstractPediatric Central Nervous System (CNS) neoplasms are the second most prevalent tumors of childhood. Further on, prognosis of this type of neoplasms still remain poor and the comprehension of the etiology and pathogenesis of the disease still remains scarce. Several reports have identified microRNAs as significant molecules in the development of central nervous system tumors and propose that they might compose key molecules underlying oncogenesis. In a previous study we have identified several miRNAs, common to different subtypes of pediatric embryonal CNS malignancies as well as, we have identified miRNAs that manifest significant dynamics with respect to their expression and the neoplasmatic subtype. Overall, 19 tumor cases from children diagnosed with embryonal brain tumors were investigated. As controls, children who suffered a sudden death underwent autopsy and were not present with any brain malignancy were used (13 samples of varying localization). Our experimental approach included microarrays covering 1211 miRNAs, which appeared to manifest tumor-specific dynamics. In conclusion, it appeared that certain miRNAs are neoplasm specific and in particular, their expression manifests linear dynamics. Thus, the investigation of miRNA expression in pediatric embryonal brain tumors might contribute towards the discovery of tumor-specific miRNA signatures, which could potentially afford the identification of gene-specific biomarkers related to diagnosis, prognosis and patient targeted therapy, as well as help us understand oncogenetic dynamics.en
dc.format.extent4
dc.language.isoeng
dc.publisherIEEE
dc.relation.ispartof2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
dc.rightsOpen
dc.subjectSignal Processing
dc.subjectBiomedical Engineering
dc.subjectComputer Vision and Pattern Recognition
dc.subjectHealth Informatics
dc.titleBioinformatics and Regression Analyses Manifest Tumor-Specific miRNA Expression Dynamics in Pediatric Embryonal Malignanciesen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Biological and Environmental Sciences
dc.contributor.institutionBiosciences Research Group
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85056605692&partnerID=8YFLogxK
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Accepted Version
dcterms.dateAccepted2018-10-29
rioxxterms.versionAM
rioxxterms.versionofrecordhttps://doi.org/10.1109/EMBC.2018.8513587
rioxxterms.licenseref.uriOther
rioxxterms.typeOther
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


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