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dc.contributor.authorSegall, Liviu
dc.contributor.authorNistor, Ionuţ
dc.contributor.authorPascual, Julio
dc.contributor.authorMucsi, Istvan
dc.contributor.authorGuirado, Lluis
dc.contributor.authorHiggins, Robert
dc.contributor.authorVan Laecke, Steven
dc.contributor.authorOberbauer, Rainer
dc.contributor.authorVan Biesen, Wim
dc.contributor.authorAbramowicz, Daniel
dc.contributor.authorGavrilovici, Cristina
dc.contributor.authorFarrington, Ken
dc.contributor.authorCovic, Adrian
dc.date.accessioned2019-11-08T01:15:19Z
dc.date.available2019-11-08T01:15:19Z
dc.date.issued2016-10-01
dc.identifier.citationSegall , L , Nistor , I , Pascual , J , Mucsi , I , Guirado , L , Higgins , R , Van Laecke , S , Oberbauer , R , Van Biesen , W , Abramowicz , D , Gavrilovici , C , Farrington , K & Covic , A 2016 , ' Criteria for and Appropriateness of Renal Transplantation in Elderly Patients With End-Stage Renal Disease : A Literature Review and Position Statement on Behalf of the European Renal Association-European Dialysis and Transplant Association Descartes Working Group and European Renal Best Practice ' , Cell Transplantation , vol. 100 , no. 10 , pp. e55-65 . https://doi.org/10.1097/TP.0000000000001367
dc.identifier.issn0963-6897
dc.identifier.otherPURE: 13324064
dc.identifier.otherPURE UUID: b57beb02-7e77-4801-a6ef-39306053e2ba
dc.identifier.otherPubMed: 27472096
dc.identifier.otherScopus: 84989285166
dc.identifier.urihttp://hdl.handle.net/2299/21857
dc.description.abstractDuring the last 20 years, waiting lists for renal transplantation (RT) have grown significantly older. However, elderly patients (ie ≥65 years of age) are still more rarely referred or accepted to waiting lists and, if enlisted, have less chances of actually receiving a kidney allograft, than younger counterparts. In this review, we looked at evidence for the benefits and risks of RT in the elderly trying to answer the following questions: Should RT be advocated for elderly patients? What should be the criteria to accept elderly patients on the waiting list for RT? What strategies might be used to increase the rate of RT in waitlisted elderly candidates? For selected elderly patients, RT was shown to be superior to dialysis in terms of patient survival. Virtually all guidelines recommend that patients should not be deemed ineligible for RT based on age alone, although a short life expectancy generally might preclude RT. Concerning the assessment of comorbidities in the elderly, special attention should be paid to cardiac evaluation and screening for malignancy. Comorbidity scores and frailty assessment scales might help the decision making on eligibility. Psychosocial issues should also be evaluated. To overcome the scarcity of organ donors, elderly RT candidates should be encouraged to consider expanded criteria donors and living donors, as alternatives to deceased standard criteria donors. It has been demonstrated that expanded criteria donor RT in patients 60 years or older is associated with higher survival rates than remaining on dialysis, whereas living donor RT is superior to all other options.en
dc.language.isoeng
dc.relation.ispartofCell Transplantation
dc.rightsOpen
dc.subjectAdult
dc.subjectAged
dc.subjectCardiovascular Diseases
dc.subjectFrail Elderly
dc.subjectHumans
dc.subjectKidney Failure, Chronic
dc.subjectKidney Transplantation
dc.subjectMiddle Aged
dc.subjectNeoplasms
dc.subjectRenal Dialysis
dc.subjectRisk Reduction Behavior
dc.subjectJournal Article
dc.subjectReview
dc.titleCriteria for and Appropriateness of Renal Transplantation in Elderly Patients With End-Stage Renal Disease : A Literature Review and Position Statement on Behalf of the European Renal Association-European Dialysis and Transplant Association Descartes Working Group and European Renal Best Practiceen
dc.contributor.institutionBasic and Clinical Science Unit
dc.contributor.institutionCentre for Health Services and Clinical Research
dc.contributor.institutionDepartment of Pharmacy, Pharmacology and Postgraduate Medicine
dc.contributor.institutionSchool of Life and Medical Sciences
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2016-10-01
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1097/TP.0000000000001367
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc/4.0/
rioxxterms.typeOther
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


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