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dc.contributor.authorBankier, Claire
dc.contributor.authorCheong, Yuen Ki
dc.contributor.authorMatharu, Rupy Kaur
dc.contributor.authorRen, Guogang
dc.contributor.authorCloutman-Green, Elaine
dc.contributor.authorCiric, Lena
dc.date.accessioned2019-11-08T01:21:25Z
dc.date.available2019-11-08T01:21:25Z
dc.date.issued2019-11-05
dc.identifier.citationBankier , C , Cheong , Y K , Matharu , R K , Ren , G , Cloutman-Green , E & Ciric , L 2019 , ' Synergistic Antibacterial Effects of Metallic Nanoparticle Combinations ' , Scientific Reports , vol. 9 , 16074 , pp. 1-8 . https://doi.org/10.1038/s41598-019-52473-2
dc.identifier.issn2045-2322
dc.identifier.otherPURE: 17625402
dc.identifier.otherPURE UUID: 63455b64-2f1e-46af-afc0-b652413e6fed
dc.identifier.otherORCID: /0000-0001-8865-1526/work/64327688
dc.identifier.otherScopus: 85074742009
dc.identifier.otherPubMed: 31690845
dc.identifier.urihttp://hdl.handle.net/2299/21870
dc.description© The Author(s) 2019.
dc.description.abstractMetallic nanoparticles have unique antimicrobial properties that make them suitable for use within medical and pharmaceutical devices to prevent the spread of infection in healthcare. The use of nanoparticles in healthcare is on the increase with silver being used in many devices. However, not all metallic nanoparticles can target and kill all disease-causing bacteria. To overcome this, a combination of several different metallic nanoparticles were used in this study to compare effects of multiple metallic nanoparticles when in combination than when used singly, as single elemental nanoparticles (SENPs), against two common hospital acquired pathogens (Staphylococcus aureus and Pseudomonas. aeruginosa). Flow cytometry LIVE/DEAD assay was used to determine rates of cell death within a bacterial population when exposed to the nanoparticles. Results were analysed using linear models to compare effectiveness of three different metallic nanoparticles, tungsten carbide (WC), silver (Ag) and copper (Cu), in combination and separately. Results show that when the nanoparticles are placed in combination (NPCs), antimicrobial effects significantly increase than when compared with SENPs (P < 0.01). This study demonstrates that certain metallic nanoparticles can be used in combination to improve the antimicrobial efficiency in destroying morphologically distinct pathogens within the healthcare and pharmaceutical industry.en
dc.format.extent8
dc.language.isoeng
dc.relation.ispartofScientific Reports
dc.subjectGeneral
dc.titleSynergistic Antibacterial Effects of Metallic Nanoparticle Combinationsen
dc.contributor.institutionCentre for Engineering Research
dc.contributor.institutionMaterials and Structures
dc.contributor.institutionBioEngineering
dc.contributor.institutionSchool of Engineering and Computer Science
dc.contributor.institutionDepartment of Engineering and Technology
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85074742009&partnerID=8YFLogxK
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1038/s41598-019-52473-2
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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