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dc.contributor.authorEmeriewen, K.
dc.contributor.authorMcAuley, William
dc.contributor.authorBeebeejaun, Mubinah
dc.contributor.authorCook, Michael T.
dc.contributor.authorSaleh, G.M.
dc.date.accessioned2019-11-13T01:12:36Z
dc.date.available2019-11-13T01:12:36Z
dc.date.issued2020-02-01
dc.identifier.citationEmeriewen , K , McAuley , W , Beebeejaun , M , Cook , M T & Saleh , G M 2020 , ' The permeability of human eyelid skin to topically applied lidocaine ' , Journal of Drug Delivery Science and Technology , vol. 55 , 101357 , pp. 4 . https://doi.org/10.1016/j.jddst.2019.101357
dc.identifier.issn1773-2247
dc.identifier.otherPURE: 17694149
dc.identifier.otherPURE UUID: 708501ea-0c83-4605-8f96-843452a094f0
dc.identifier.otherScopus: 85075008292
dc.identifier.otherORCID: /0000-0002-1481-3032/work/93471156
dc.identifier.urihttp://hdl.handle.net/2299/21889
dc.description© 2019 Published by Elsevier B.V.
dc.description.abstractThis work investigated the permeability of lidocaine across human eyelid skin and compared this with published data for abdominal skin to understand the characteristics of this type of skin and whether topical anaesthesia for eyelid surgery may be feasible. Eyelid skin is thought to have a relatively high permeability to drugs, however how this compares to other body sites has not been previously quantified. Lidocaine solutions at pH 7.0 and 5.5 were applied to human eyelid skin mounted in Franz diffusion cells. Anatomical features of eyelid skin that may be linked to its increased permeability, superficial corneocyte area and stratum corneum (SC) thickness were measured using light microscopy. Steady-state fluxes of lidocaine at pH 7.0 and pH 5.5 were 283.9 and 41.0 μg/cm2/hr, 2.4 and 3.2 times greater respectively than literature values for abdominal skin. Superficial eyelid corneocyte area (800.5 μm2) was 35% smaller and the eyelid SC thickness (14.9 μm) was 31% thinner than reported abdominal skin values. These suggest that a shorter diffusional pathlength across the eyelid SC contributes to increased lidocaine permeability. The relatively high permeability of eyelid skin to lidocaine indicates considerable potential for achieving strong topical anaesthetic effects at this site.en
dc.language.isoeng
dc.relation.ispartofJournal of Drug Delivery Science and Technology
dc.subjectEyelid skin
dc.subjectSkin permeation
dc.subjectTopical anaesthesia
dc.subjectTopical drug delivery
dc.subjectPharmaceutical Science
dc.titleThe permeability of human eyelid skin to topically applied lidocaineen
dc.contributor.institutionDepartment of Clinical and Pharmaceutical Sciences
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionSkin and Nail Group
dc.contributor.institutionPharmaceutics
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.contributor.institutionDepartment of Clinical, Pharmaceutical and Biological Science
dc.description.statusPeer reviewed
dc.date.embargoedUntil2020-10-31
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85075008292&partnerID=8YFLogxK
rioxxterms.versionAM
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.jddst.2019.101357
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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