dc.contributor.author | Patel, Simmi | |
dc.contributor.author | McAuley, William | |
dc.contributor.author | Cook, Michael T. | |
dc.contributor.author | Sun, Yi | |
dc.contributor.author | Hamdy, Shaheen | |
dc.contributor.author | Liu, Fang | |
dc.date.accessioned | 2019-11-14T01:11:48Z | |
dc.date.available | 2019-11-14T01:11:48Z | |
dc.date.issued | 2019-11-09 | |
dc.identifier.citation | Patel , S , McAuley , W , Cook , M T , Sun , Y , Hamdy , S & Liu , F 2019 , ' The Swallowing Characteristics of Thickeners, Jellies and Yoghurt Observed Using an In Vitro Model ' , Dysphagia , pp. 1-11 . https://doi.org/10.1007/s00455-019-10074-1 | |
dc.identifier.issn | 1432-0460 | |
dc.identifier.uri | http://hdl.handle.net/2299/21892 | |
dc.description | © The Author(s) 2019 Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | |
dc.description.abstract | Drinks and foods may be thickened to improve swallowing safety for dysphagia patients, but the resultant consistencies are not always palatable. Characterising alternative appetising foods is an important task. The study aims to characterise the in vitro swallowing behaviour of specifically formulated thickened dysphagia fluids containing xanthan gum and/or starch with standard jellies and yoghurt using a validated mechanical model, the “Cambridge Throat”. Observing from the side, the model throat can follow an experimental oral transit time (in vitro-OTT) and a bolus length (BL) at the juncture of the pharynx and larynx, to assess the velocity and cohesion of bolus flow. Our results showed that higher thickener concentration produced longer in vitro-OTT and shorter BL. At high concentration (spoon-thick), fluids thickened with starch-based thickener showed significantly longer in vitro-OTT than when xanthan gum-based thickener was used (84.5 s ± 34.5 s and 5.5 s ± 1.6 s, respectively, p < 0.05). In contrast, at low concentration (nectar-like), fluids containing xanthan gum-based thickener demonstrated shorter BL than those of starch-based thickener (6.4 mm ± 0.5 mm and 8.2 mm ± 0.8 mm, respectively, p < 0.05). The jellies and yoghurt had comparable in vitro-OTT and BL to thickeners at high concentrations (honey-like and spoon-thick), indicating similar swallowing characteristics. The in vitro results showed correlation with published in vivo data though the limitations of applying the in vitro swallowing test for dysphagia studies were noted. These findings contribute useful information for designing new thickening agents and selecting alternative and palatable safe-to-swallow foods. | en |
dc.format.extent | 11 | |
dc.format.extent | 1485769 | |
dc.language.iso | eng | |
dc.relation.ispartof | Dysphagia | |
dc.subject | Deglutition | |
dc.subject | Deglutition disorder | |
dc.subject | Dysphagia | |
dc.subject | In vitro | |
dc.subject | Oral transit | |
dc.subject | Rheology | |
dc.subject | Swallowing | |
dc.subject | Texture | |
dc.subject | Otorhinolaryngology | |
dc.subject | Gastroenterology | |
dc.subject | Speech and Hearing | |
dc.title | The Swallowing Characteristics of Thickeners, Jellies and Yoghurt Observed Using an In Vitro Model | en |
dc.contributor.institution | Department of Clinical and Pharmaceutical Sciences | |
dc.contributor.institution | Centre for Research into Topical Drug Delivery and Toxicology | |
dc.contributor.institution | Pharmaceutics | |
dc.contributor.institution | Pharmaceutical Analysis and Product Characterisation | |
dc.contributor.institution | Bioadhesive Drug Delivery Group | |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Skin and Nail Group | |
dc.contributor.institution | Department of Computer Science | |
dc.contributor.institution | School of Physics, Engineering & Computer Science | |
dc.contributor.institution | Centre for Computer Science and Informatics Research | |
dc.contributor.institution | Biocomputation Research Group | |
dc.description.status | Peer reviewed | |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85074831334&partnerID=8YFLogxK | |
rioxxterms.versionofrecord | 10.1007/s00455-019-10074-1 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |