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dc.contributor.authorSoelter, Jan
dc.contributor.authorSchumacher, Jan
dc.contributor.authorSpors, Hartwig
dc.contributor.authorSchmuker, Michael
dc.date.accessioned2020-01-12T01:09:53Z
dc.date.available2020-01-12T01:09:53Z
dc.date.issued2020-01-09
dc.identifier.citationSoelter , J , Schumacher , J , Spors , H & Schmuker , M 2020 , ' Computational exploration of molecular receptive fields in the olfactory bulb reveals a glomerulus-centric chemical map ' , Scientific Reports , vol. 10 , 77 , pp. 1-16 . https://doi.org/10.1038/s41598-019-56863-4
dc.identifier.issn2045-2322
dc.identifier.otherPURE: 16546234
dc.identifier.otherPURE UUID: c0789fe3-084d-40cb-a074-d298001dff14
dc.identifier.otherScopus: 85077698935
dc.identifier.otherPubMed: 31919393
dc.identifier.urihttp://hdl.handle.net/2299/22068
dc.description© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
dc.description.abstractProgress in olfactory research is currently hampered by incomplete knowledge about chemical receptive ranges of primary receptors. Moreover, the chemical logic underlying the arrangement of computational units in the olfactory bulb has still not been resolved. We undertook a large-scale approach at characterising molecular receptive ranges (MRRs) of glomeruli in the dorsal olfactory bulb (dOB) innervated by the MOR18-2 olfactory receptor, also known as Olfr78, with human ortholog OR51E2. Guided by an iterative approach that combined biological screening and machine learning, we selected 214 odorants to characterise the response of MOR18-2 and its neighbouring glomeruli. We found that a combination of conventional physico-chemical and vibrational molecular descriptors performed best in predicting glomerular responses using nonlinear Support-Vector Regression. We also discovered several previously unknown odorants activating MOR18-2 glomeruli, and obtained detailed MRRs of MOR18-2 glomeruli and their neighbours. Our results confirm earlier findings that demonstrated tunotopy, that is, glomeruli with similar tuning curves tend to be located in spatial proximity in the dOB. In addition, our results indicate chemotopy, that is, a preference for glomeruli with similar physico-chemical MRR descriptions being located in spatial proximity. Together, these findings suggest the existence of a partial chemical map underlying glomerular arrangement in the dOB. Our methodology that combines machine learning and physiological measurements lights the way towards future high-throughput studies to deorphanise and characterise structure-activity relationships in olfaction.en
dc.format.extent16
dc.language.isoeng
dc.relation.ispartofScientific Reports
dc.subjectGeneral
dc.titleComputational exploration of molecular receptive fields in the olfactory bulb reveals a glomerulus-centric chemical mapen
dc.contributor.institutionSchool of Computer Science
dc.contributor.institutionCentre of Data Innovation Research
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85077698935&partnerID=8YFLogxK
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1038/s41598-019-56863-4
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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