dc.contributor.author | Apergis-Schoute, Annemieke M | |
dc.contributor.author | Bijleveld, Bastiaan | |
dc.contributor.author | Gillan, Claire M. | |
dc.contributor.author | Fineberg, Naomi | |
dc.contributor.author | Sahakian, Barbara J. | |
dc.date.accessioned | 2020-01-30T11:14:43Z | |
dc.date.available | 2020-01-30T11:14:43Z | |
dc.date.issued | 2018-11-30 | |
dc.identifier.citation | Apergis-Schoute , A M , Bijleveld , B , Gillan , C M , Fineberg , N & Sahakian , B J 2018 , ' Hyperconnectivity of the ventromedial prefrontal cortex in obsessive-compulsive disorder ' , Brain and Neuroscience Advances . https://doi.org/10.1177/2398212818808710 | |
dc.identifier.issn | 2398-2128 | |
dc.identifier.uri | http://hdl.handle.net/2299/22142 | |
dc.description.abstract | Neuroimaging research has highlighted maladaptive thalamo-cortico-striatal interactions in obsessive-compulsive disorder as well as a more general deficit in prefrontal functioning linked with compromised executive functioning. More specifically, dysfunction in the ventromedial prefrontal cortex, a central hub in coordinating flexible behaviour, is thought to be central to obsessive-compulsive disorder symptomatology. We sought to determine the intrinsic alterations of the ventromedial prefrontal cortex in obsessive-compulsive disorder employing resting-state functional connectivity magnetic resonance imaging analyses with a ventromedial prefrontal cortex seed region of interest. A total of 38 obsessive-compulsive disorder patients and 33 matched controls were included in our analyses. We found widespread ventromedial prefrontal cortex hyperconnectivity during rest in patients with obsessive-compulsive disorder, displaying increased connectivity with its own surrounding region in addition to hyperconnectivity with several areas along the thalamo-cortico-striatal loop: thalamus, caudate and frontal gyrus. Obsessive-compulsive disorder patients also exhibited increased functional connectivity from the ventromedial prefrontal cortex to temporal and occipital lobes, cerebellum and the motor cortex, reflecting ventromedial prefrontal cortex hyperconnectivity in large-scale brain networks. Furthermore, hyperconnectivity of the ventromedial prefrontal cortex and caudate correlated with obsessive-compulsive disorder symptomatology. Additionally, we used three key thalamo-cortico-striatal regions that were hyperconnected with our ventromedial prefrontal cortex seed as supplementary seed regions, revealing hypoconnectivity along the orbito- and lateral prefrontal cortex-striatal pathway. Taken together, these results confirm a central role of a hyperconnected ventromedial prefrontal cortex in obsessive-compulsive disorder, with a special role for maladaptive crosstalk with the caudate, and indications for hypoconnectivity along the lateral and orbito frontal pathways. | en |
dc.format.extent | 10 | |
dc.format.extent | 521550 | |
dc.language.iso | eng | |
dc.relation.ispartof | Brain and Neuroscience Advances | |
dc.title | Hyperconnectivity of the ventromedial prefrontal cortex in obsessive-compulsive disorder | en |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Department of Clinical and Pharmaceutical Sciences | |
dc.contributor.institution | Centre for Health Services and Clinical Research | |
dc.contributor.institution | Cognitive Neuropsychology | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | 10.1177/2398212818808710 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |