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dc.contributor.authorPattison, Natalie
dc.contributor.authorArul, Nish
dc.contributor.authorConnolly, Bronwen
dc.contributor.authorO'Gara, Geraldine
dc.date.accessioned2020-02-19T01:15:30Z
dc.date.available2020-02-19T01:15:30Z
dc.date.issued2019-12-22
dc.identifier.citationPattison , N , Arul , N , Connolly , B & O'Gara , G 2019 , ' Synthesis of qualitative research studies regarding the factors surrounding UK critical care trial infrastructure ' , BMJ Open , vol. 9 , e030815 , pp. 1-8 . https://doi.org/10.1136/bmjopen-2019-030815
dc.identifier.issn2044-6055
dc.identifier.otherPURE: 17785196
dc.identifier.otherPURE UUID: 46956ef0-e80d-4bdb-85ee-7a5e0517c662
dc.identifier.otherORCID: /0000-0002-6771-8733/work/68990746
dc.identifier.otherScopus: 85077195837
dc.identifier.urihttp://hdl.handle.net/2299/22297
dc.description© 2019 Author(s). Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ
dc.description.abstractConducting clinical trials in critical care is integral to improving patient care. Unique practical and ethical considerations exist in this patient population that make patient recruitment challenging, including narrow recruitment timeframes and obtaining patient consent often in time-critical situations. Units currently vary significantly in their ability to recruit according to infrastructure and level of research activity. Aim : To identify variability in the research infrastructure of UK intensive care units (ICUs) and their ability to conduct research and recruit patients into clinical trials. Design: We evaluated factors related to intensive care patient enrolment into clinical trials in the UK. This consisted of a qualitative synthesis carried out with two datasets of in-depth interviews (distinct participants across the two datasets) conducted with 27 intensive care consultants (n=9), research nurses (n=17) and trial coordinators (n=1) from 27 units across the UK. Primary and secondary analysis of two datasets (one dataset had been analysed previously) was undertaken in the thematic analysis. Findings: The synthesis yielded an overarching core theme of Normalising Research, characterised by motivations for promoting research and fostering research-active cultures within resource constraints, with six themes under this to explain the factors influencing critical care research capacity: Organisational, Human, Study, Practical resources, Clinician, and Patient/family factors. There was a strong sense of integrating research in routine clinical practice, and recommendations are outlined. Conclusions: The central and transferable tenet of Normalising Research advocates the importance of developing a culture where research is inclusive alongside clinical practice in routine patient care and is requisite for all healthcare individuals from organisational to direct patient contact level.en
dc.format.extent8
dc.language.isoeng
dc.relation.ispartofBMJ Open
dc.rightsOpen
dc.titleSynthesis of qualitative research studies regarding the factors surrounding UK critical care trial infrastructureen
dc.contributor.institutionSchool of Health and Social Work
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Health and Social Work
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2019-12-22
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1136/bmjopen-2019-030815
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc/4.0/
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


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