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dc.contributor.authorLivingstone, Katherine M
dc.contributor.authorCelis-Morales, Carlos
dc.contributor.authorHoeller, Ulrich
dc.contributor.authorLambrinou, Christina P
dc.contributor.authorMoschonis, George
dc.contributor.authorMacready, Anna L
dc.contributor.authorFallaize, Rosalind
dc.contributor.authorBaur, Manuela
dc.contributor.authorRoos, Franz F
dc.contributor.authorBendik, Igor
dc.contributor.authorGrimaldi, Keith
dc.contributor.authorNavas-Carretero, Santiago
dc.contributor.authorSan-Cristobal, Rodrigo
dc.contributor.authorWeber, Peter
dc.contributor.authorDrevon, Christian A
dc.contributor.authorManios, Yannis
dc.contributor.authorTraczyk, Iwona
dc.contributor.authorGibney, Eileen R
dc.contributor.authorLovegrove, Julie A
dc.contributor.authorSaris, Wim H
dc.contributor.authorDaniel, Hannelore
dc.contributor.authorGibney, Mike
dc.contributor.authorMartinez, J Alfredo
dc.contributor.authorBrennan, Lorraine
dc.contributor.authorHill, Tom R
dc.contributor.authorMathers, John C
dc.contributor.authorFood4Me Study
dc.date.accessioned2020-02-22T01:05:35Z
dc.date.available2020-02-22T01:05:35Z
dc.date.issued2017-02-01
dc.identifier.citationLivingstone , K M , Celis-Morales , C , Hoeller , U , Lambrinou , C P , Moschonis , G , Macready , A L , Fallaize , R , Baur , M , Roos , F F , Bendik , I , Grimaldi , K , Navas-Carretero , S , San-Cristobal , R , Weber , P , Drevon , C A , Manios , Y , Traczyk , I , Gibney , E R , Lovegrove , J A , Saris , W H , Daniel , H , Gibney , M , Martinez , J A , Brennan , L , Hill , T R , Mathers , J C & Food4Me Study 2017 , ' Weekday sunlight exposure, but not vitamin D intake, influences the association between vitamin D receptor genotype and circulating concentration 25-hydroxyvitamin D in a pan-European population : the Food4Me study ' , Molecular nutrition & food research , vol. 61 , no. 2 . https://doi.org/10.1002/mnfr.201600476
dc.identifier.issn1613-4125
dc.identifier.otherPURE: 10520508
dc.identifier.otherPURE UUID: 21fc58ad-0321-4a07-b4b2-53a1dce3e07e
dc.identifier.otherPubMed: 27682437
dc.identifier.otherScopus: 85000420307
dc.identifier.urihttp://hdl.handle.net/2299/22331
dc.description© 2016 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
dc.description.abstractSCOPE: Little is known about diet- and environment-gene interactions on 25-hydroxyvitamin D (25(OH)D concentration. This cross-sectional study aimed to investigate i) predictors of 25(OH)D concentration and relationships with vitamin D genotypes and ii) whether dietary vitamin D intake and sunlight exposure modified these relationships. METHODS AND RESULTS: Participants from the Food4Me study (n = 1312; age 18-79) were genotyped for vitamin D receptor (VDR) and vitamin D binding protein at baseline and a genetic risk score was calculated. Dried blood spot samples were assayed for 25(OH)D concentration and dietary and lifestyle information collected. Circulating 25(OH)D concentration was lower with increasing genetic risk score, lower in females than males, higher in supplement users than non-users and higher in summer than winter. Carriage of the minor VDR allele was associated with lower 25(OH)D concentration in participants with the least sunlight exposure. Vitamin D genotype did not influence the relationship between vitamin D intake and 25(OH)D concentration. CONCLUSION: Age, sex, dietary vitamin D intake, country, sunlight exposure, season and vitamin D genetic risk score were associated with circulating 25(OH)D concentration in a pan-European population. The relationship between VDR genotype and 25(OH)D concentration may be influenced by weekday sunlight exposure but not dietary vitamin D intake. This article is protected by copyright. All rights reserved.en
dc.format.extent10
dc.language.isoeng
dc.relation.ispartofMolecular nutrition & food research
dc.titleWeekday sunlight exposure, but not vitamin D intake, influences the association between vitamin D receptor genotype and circulating concentration 25-hydroxyvitamin D in a pan-European population : the Food4Me studyen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Biological and Environmental Sciences
dc.contributor.institutionWeight and Obesity Research Group
dc.contributor.institutionAgriculture, Food and Veterinary Sciences
dc.description.statusPeer reviewed
dc.date.embargoedUntil2017-09-28
rioxxterms.versionAM
rioxxterms.versionofrecordhttps://doi.org/10.1002/mnfr.201600476
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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