dc.contributor.author | Lykoudi, Alexandra | |
dc.contributor.author | Kolialexi, Aggeliki | |
dc.contributor.author | Lambrou, George I | |
dc.contributor.author | Braoudaki, Maria | |
dc.contributor.author | Siristatidis, Charalampos | |
dc.contributor.author | Papaioanou, George Konstantinos | |
dc.contributor.author | Tzetis, Maria | |
dc.contributor.author | Mavrou, Ariadni | |
dc.contributor.author | Papantoniou, Nikolas | |
dc.date.accessioned | 2020-03-05T01:04:21Z | |
dc.date.available | 2020-03-05T01:04:21Z | |
dc.date.issued | 2018-01-01 | |
dc.identifier.citation | Lykoudi , A , Kolialexi , A , Lambrou , G I , Braoudaki , M , Siristatidis , C , Papaioanou , G K , Tzetis , M , Mavrou , A & Papantoniou , N 2018 , ' Dysregulated placental microRNAs in Early and Late onset Preeclampsia ' , Placenta , vol. 61 , pp. 24-32 . https://doi.org/10.1016/j.placenta.2017.11.005 | |
dc.identifier.issn | 0143-4004 | |
dc.identifier.uri | http://hdl.handle.net/2299/22384 | |
dc.description | Copyright © 2017. Published by Elsevier Ltd. | |
dc.description.abstract | INTRODUCTION: To determine the miRNA expression profile in placentas complicated by Preeclampsia (PE) and compare it to uncomplicated pregnancies. METHODS: Sixteen placentas from women with PE, [11 with early onset PE (EOPE) and 5 with late onset PE (LOPE)], as well as 8 placentas from uncomplicated pregnancies were analyzed using miRNA microarrays. For statistical analyses the MATLAB® simulation environment was applied. The over-expression of miR-518a-5p was verified using Quantitative Real-Time Polymerase Chain Reaction. RESULTS: Forty four miRNAs were found dysregulated in PE complicated placentas. Statistical analysis revealed that miR-431, miR-518a-5p and miR-124* were over-expressed in EOPE complicated placentas as compared to controls, whereas miR-544 and miR-3942 were down-regulated in EOPE. When comparing the miRNA expression profile in cases with PE and PE-growth restricted fetuses (FGR), miR-431 and miR-518a-5p were found over-expressed in pregnancies complicated by FGR. DISCUSSION: Since specific miRNAs can differentiate EOPE and LOPE from uncomplicated placentas, they may be considered as putative PE-specific biomarkers. MiR-518a-5p emerged as a potential diagnostic indicator for EOPE cases as well as for PE-FGR complicated placentas, indicating a potential link to the severity of the disease. | en |
dc.format.extent | 9 | |
dc.format.extent | 584272 | |
dc.language.iso | eng | |
dc.relation.ispartof | Placenta | |
dc.subject | microRNAs | |
dc.subject | preeclampsia | |
dc.title | Dysregulated placental microRNAs in Early and Late onset Preeclampsia | en |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Biosciences Research Group | |
dc.contributor.institution | Centre for Research in Mechanisms of Disease and Drug Discovery | |
dc.contributor.institution | Department of Clinical, Pharmaceutical and Biological Science | |
dc.contributor.institution | Centre for Future Societies Research | |
dc.description.status | Peer reviewed | |
dc.date.embargoedUntil | 2018-11-14 | |
rioxxterms.versionofrecord | 10.1016/j.placenta.2017.11.005 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |