dc.contributor.author | Gue, Ying X. | |
dc.contributor.author | Gorog, Diana A. | |
dc.date.accessioned | 2020-03-27T01:06:37Z | |
dc.date.available | 2020-03-27T01:06:37Z | |
dc.date.issued | 2017-09-01 | |
dc.identifier.citation | Gue , Y X & Gorog , D A 2017 , ' Importance of endogenous fibrinolysis in platelet thrombus formation ' , International Journal of Molecular Sciences (IJMS) , vol. 18 , no. 9 , 1850 . https://doi.org/10.3390/ijms18091850 | |
dc.identifier.issn | 1661-6596 | |
dc.identifier.other | PubMedCentral: PMC5618499 | |
dc.identifier.uri | http://hdl.handle.net/2299/22511 | |
dc.description | © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | |
dc.description.abstract | The processes of thrombosis and coagulation are finely regulated by endogenous fibrinolysis maintaining healthy equilibrium. When the balance is altered in favour of platelet activation and/or coagulation, or if endogenous fibrinolysis becomes less efficient, pathological thrombosis can occur. Arterial thrombosis remains a major cause of morbidity and mortality in the world despite advances in medical therapies. The role endogenous fibrinolysis in the pathogenesis of arterial thrombosis has gained increasing attention in recent years as it presents novel ways to prevent and treat existing diseases. In this review article, we discuss the role of endogenous fibrinolysis in platelet thrombus formation, methods of measurement of fibrinolytic activity, its role in predicting cardiovascular diseases and clinical outcomes and future directions. | en |
dc.format.extent | 15 | |
dc.format.extent | 266092 | |
dc.language.iso | eng | |
dc.relation.ispartof | International Journal of Molecular Sciences (IJMS) | |
dc.subject | Cardiovascular | |
dc.subject | Endogenous | |
dc.subject | Fibrinolysis | |
dc.subject | Platelets | |
dc.subject | Spontaneous | |
dc.subject | Thrombolysis | |
dc.subject | Thrombosis | |
dc.subject | Catalysis | |
dc.subject | Molecular Biology | |
dc.subject | Computer Science Applications | |
dc.subject | Spectroscopy | |
dc.subject | Physical and Theoretical Chemistry | |
dc.subject | Organic Chemistry | |
dc.subject | Inorganic Chemistry | |
dc.title | Importance of endogenous fibrinolysis in platelet thrombus formation | en |
dc.contributor.institution | Department of Pharmacy, Pharmacology and Postgraduate Medicine | |
dc.contributor.institution | University of Hertfordshire | |
dc.description.status | Peer reviewed | |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85028355221&partnerID=8YFLogxK | |
rioxxterms.versionofrecord | 10.3390/ijms18091850 | |
rioxxterms.type | Other | |
herts.preservation.rarelyaccessed | true | |