dc.contributor.author | Vestri, Ambra | |
dc.contributor.author | Pearce, Amanda K. | |
dc.contributor.author | Cavanagh, Robert | |
dc.contributor.author | Styliari, Ioanna D. | |
dc.contributor.author | Sanders, Carlos | |
dc.contributor.author | Couturaud, Benoit | |
dc.contributor.author | Schenone, Silvia | |
dc.contributor.author | Taresco, Vincenzo | |
dc.contributor.author | Jakobsen, Rasmus R. | |
dc.contributor.author | Howdle, Steven M. | |
dc.contributor.author | Musumeci, Francesca | |
dc.contributor.author | Sagnelli, Domenico | |
dc.date.accessioned | 2020-04-16T00:11:04Z | |
dc.date.available | 2020-04-16T00:11:04Z | |
dc.date.issued | 2020-02-01 | |
dc.identifier.citation | Vestri , A , Pearce , A K , Cavanagh , R , Styliari , I D , Sanders , C , Couturaud , B , Schenone , S , Taresco , V , Jakobsen , R R , Howdle , S M , Musumeci , F & Sagnelli , D 2020 , ' Starch/Poly(glycerol-adipate) Nanocomposites: A Novel Oral Drug Delivery Device ' , Coatings , vol. 10 , no. 2 , 125 . https://doi.org/10.3390/coatings10020125 | |
dc.identifier.other | ORCID: /0000-0002-7476-2994/work/72308377 | |
dc.identifier.uri | http://hdl.handle.net/2299/22588 | |
dc.description | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | |
dc.description.abstract | Biocompatible and bio-based materials are an appealing resource for the pharmaceutical industry. Poly(glycerol-adipate) (PGA) is a biocompatible and biodegradable polymer that can be used to produce self-assembled nanoparticles (NPs) able to encapsulate active ingredients, with encouraging perspectives for drug delivery purposes. Starch is a versatile, inexpensive, and abundant polysaccharide that can be effectively applied as a bio-scaffold for other molecules in order to enrich it with new appealing properties. In this work, the combination of PGA NPs and starch films proved to be a suitable biopolymeric matrix carrier for the controlled release preparation of hydrophobic drugs. Dynamic Light Scattering (DLS) was used to determine the size of drug-loaded PGA NPs, while the improvement of the apparent drug water solubility was assessed by UV-vis spectroscopy. In vitro biological assays were performed against cancer cell lines and bacteria strains to confirm that drug-loaded PGA NPs maintained the effective activity of the therapeutic agents. Dye-conjugated PGA was then exploited to track the NP release profile during the starch/PGA nanocomposite film digestion, which was assessed using digestion models mimicking physiological conditions. The collected data provide a clear indication of the suitability of our biodegradable carrier system for oral drug delivery. | en |
dc.format.extent | 15 | |
dc.format.extent | 2728994 | |
dc.language.iso | eng | |
dc.relation.ispartof | Coatings | |
dc.subject | Biocompatible | |
dc.subject | Biomaterial | |
dc.subject | Drug delivery | |
dc.subject | Nanocomposites | |
dc.subject | Nanoparticles | |
dc.subject | Poly(glycerol-adipate) | |
dc.subject | Polymer | |
dc.subject | Starch | |
dc.subject | Surfaces and Interfaces | |
dc.subject | Surfaces, Coatings and Films | |
dc.subject | Materials Chemistry | |
dc.title | Starch/Poly(glycerol-adipate) Nanocomposites: A Novel Oral Drug Delivery Device | en |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Department of Pharmacy, Pharmacology and Postgraduate Medicine | |
dc.contributor.institution | Centre for Research into Topical Drug Delivery and Toxicology | |
dc.contributor.institution | Department of Clinical, Pharmaceutical and Biological Science | |
dc.description.status | Peer reviewed | |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85080899897&partnerID=8YFLogxK | |
rioxxterms.versionofrecord | 10.3390/coatings10020125 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |