dc.contributor.author | Haddow, Peter | |
dc.contributor.author | McAuley, William | |
dc.contributor.author | Kirton, Stewart | |
dc.contributor.author | Cook, Michael T. | |
dc.date.accessioned | 2020-05-09T00:10:16Z | |
dc.date.available | 2020-05-09T00:10:16Z | |
dc.date.issued | 2020-05-06 | |
dc.identifier.citation | Haddow , P , McAuley , W , Kirton , S & Cook , M T 2020 , ' Poly(N-isopropyl acrylamide) – poly(ethylene glycol) – poly(N-isopropyl acrylamide) as a thermoreversible gelator for topical administration ' , Materials Advances , vol. 2020 , no. 3 , d0ma00080a . https://doi.org/10.1039/D0MA00080A | |
dc.identifier.uri | http://hdl.handle.net/2299/22673 | |
dc.description | This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported licence: https://creativecommons.org/licenses/by-nc/3.0/. | |
dc.description.abstract | Poly(N-isopropyl acrylamide) – block– poly(ethylene glycol) – block– poly(N-isopropyl acrylamide) is known to exhibit a thermally-induced solution-to-gel transition in water, which may be exploited for biomedical applications. This “thermoreversible gelator” has great potential for application in topical drug delivery to the surfaces of the body such as the skin, eye, and vagina, but this has not yet been evaluated. This study evaluates PNIPAM98-PEG122-PNIPAM98 as a thermoreversible gelator for vaginal drug delivery, for the first time evaluating the effect of polymer concentration on gelation, studying rheological parameters relevant to topicals, measuring dissolution rates, stability and the phenomemon of mucoadhesion. Two drugs relevant to vaginal administration, progesterone and tenofovir disoproxil fumarate are investigated for use in the thermoreversible gelators, studying both hydrophobic and hydrophilic drug solubilisation and release. Throughout the study, comparison is made with poloxamer 407, the most commonly studied thermoreversible gelator. PNIPAM98-PEG122-PNIPAM98 exhibits several advantages for topical drug delivery, having low viscosity at room temperature to allow easy application, then exhibiting a gelation just below body temperature to form a viscous gel which is resistant to dissolution and relatively mucoadhesive. Drug release is highly dependent on temperature, with elevation to body temperature resulting in a dramatic retardation of progesterone release, which may be used in future medicines to provide sustained delivery of hydrophobic xenobiotics. | en |
dc.format.extent | 1908788 | |
dc.language.iso | eng | |
dc.relation.ispartof | Materials Advances | |
dc.title | Poly(N-isopropyl acrylamide) – poly(ethylene glycol) – poly(N-isopropyl acrylamide) as a thermoreversible gelator for topical administration | en |
dc.contributor.institution | Department of Clinical and Pharmaceutical Sciences | |
dc.contributor.institution | Centre for Research into Topical Drug Delivery and Toxicology | |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Skin and Nail Group | |
dc.contributor.institution | Pharmaceutics | |
dc.contributor.institution | Pharmaceutical Analysis and Product Characterisation | |
dc.contributor.institution | Centre for Health Services and Clinical Research | |
dc.contributor.institution | Psychopharmacology, Drug Misuse and Novel Psychoactive Substances Unit | |
dc.contributor.institution | Natural Product Chemistry and Drug Design | |
dc.contributor.institution | Department of Clinical, Pharmaceutical and Biological Science | |
dc.contributor.institution | Centre for Research in Mechanisms of Disease and Drug Discovery | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | 10.1039/D0MA00080A | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |