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dc.contributor.authorD'Andrea, David
dc.contributor.authorBlack, Peter C.
dc.contributor.authorZargar, Homayoun
dc.contributor.authorZargar-Shoshtari, Kamran
dc.contributor.authorZehetmayer, Sonja
dc.contributor.authorFairey, Adrian S.
dc.contributor.authorMertens, Laura S.
dc.contributor.authorDinney, Colin P.
dc.contributor.authorMir, Maria C.
dc.contributor.authorKrabbe, Laura Maria
dc.contributor.authorCookson, Michael S.
dc.contributor.authorJacobsen, Niels Erik
dc.contributor.authorMontgomery, Jeffrey S.
dc.contributor.authorVasdev, Nikhil
dc.contributor.authorYu, Evan Y.
dc.contributor.authorXylinas, Evanguelos
dc.contributor.authorCampain, Nicholas J.
dc.contributor.authorKassouf, Wassim
dc.contributor.authorDall'Era, Marc A.
dc.contributor.authorSeah, Jo An
dc.contributor.authorErcole, Cesar E.
dc.contributor.authorHorenblas, Simon
dc.contributor.authorSridhar, Srikala S.
dc.contributor.authorMcGrath, John S.
dc.contributor.authorAning, Jonathan
dc.contributor.authorWright, Jonathan L.
dc.contributor.authorThorpe, Andrew C.
dc.contributor.authorMorgan, Todd M.
dc.contributor.authorHolzbeierlein, Jeffrey M.
dc.contributor.authorBivalacqua, Trinity J.
dc.contributor.authorNorth, Scott
dc.contributor.authorBarocas, Daniel A.
dc.contributor.authorLotan, Yair
dc.contributor.authorGrivas, Petros
dc.contributor.authorStephenson, Andrew J.
dc.contributor.authorShah, Jay B.
dc.contributor.authorvan Rhijn, Bas W.
dc.contributor.authorDaneshmand, Siamak
dc.contributor.authorSpiess, Philippe E.
dc.contributor.authorShariat, Shahrokh F.
dc.date.accessioned2020-05-20T00:10:46Z
dc.date.available2020-05-20T00:10:46Z
dc.date.issued2020-02-11
dc.identifier.citationD'Andrea , D , Black , P C , Zargar , H , Zargar-Shoshtari , K , Zehetmayer , S , Fairey , A S , Mertens , L S , Dinney , C P , Mir , M C , Krabbe , L M , Cookson , M S , Jacobsen , N E , Montgomery , J S , Vasdev , N , Yu , E Y , Xylinas , E , Campain , N J , Kassouf , W , Dall'Era , M A , Seah , J A , Ercole , C E , Horenblas , S , Sridhar , S S , McGrath , J S , Aning , J , Wright , J L , Thorpe , A C , Morgan , T M , Holzbeierlein , J M , Bivalacqua , T J , North , S , Barocas , D A , Lotan , Y , Grivas , P , Stephenson , A J , Shah , J B , van Rhijn , B W , Daneshmand , S , Spiess , P E & Shariat , S F 2020 , ' Impact of sex on response to neoadjuvant chemotherapy in patients with bladder cancer ' , Urologic Oncology: Seminars and Original Investigations . https://doi.org/10.1016/j.urolonc.2020.01.010
dc.identifier.issn1078-1439
dc.identifier.otherPURE: 20809057
dc.identifier.otherPURE UUID: bdd00d2f-6dfa-4c47-af1a-fa49cb9cba3f
dc.identifier.otherScopus: 85079152713
dc.identifier.urihttp://hdl.handle.net/2299/22726
dc.description© 2020 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/.
dc.description.abstractObjective: To assess the effect of patient's sex on response to neoadjuvant chemotherapy (NAC) in patients with clinically nonmetastatic muscle-invasive bladder cancer (MIBC). Methods: Complete pathologic response, defined as ypT0N0 at radical cystectomy, and downstaging were evaluated using sex-adjusted univariable and multivariable logistic regression modeling. We used interaction terms to account for age of menopause and smoking status. The association of sex with overall survival and cancer-specific survival was evaluated using Cox regression analyses. Results: A total of 1,031 patients were included in the analysis, 227 (22%) of whom were female. Female patients had a higher rate of extravesical disease extension (P = 0.01). After the administration of NAC, ypT stage was equally distributed between sexes (P = 0.39). On multivariable logistic regression analyses, there was no difference between the sexes or age of menopause with regards to ypT0N0 rates or downstaging (all P > 0.5). On Cox regression analyses, sex was associated with neither overall survival (hazard ratio 1.04, 95% confidence interval 0.75–1.45, P = 0.81) nor cancer-specific survival (hazard ratio 1.06, 95% confidence interval 0.71–1.58, P = 0.77). Conclusion: Our study generates the hypothesis that NAC equalizes the preoperative disparity in pathologic stage between males and females suggesting a possible differential response between sexes. This might be the explanation underlying the comparable survival outcomes between sexes despite females presenting with more advanced tumor stage.en
dc.language.isoeng
dc.relation.ispartofUrologic Oncology: Seminars and Original Investigations
dc.rightsEmbargoed
dc.subjectBladder cancer
dc.subjectNeoadjuvant chemotherapy
dc.subjectResponse
dc.subjectSex
dc.subjectOncology
dc.subjectUrology
dc.titleImpact of sex on response to neoadjuvant chemotherapy in patients with bladder canceren
dc.contributor.institutionExtracellular Vesicle Research Unit
dc.contributor.institutionBasic and Clinical Science Unit
dc.contributor.institutionCentre for Health Services and Clinical Research
dc.contributor.institutionDepartment of Clinical and Pharmaceutical Sciences
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Clinical, Pharmaceutical and Biological Science
dc.description.statusPeer reviewed
dc.date.embargoedUntil2021-02-11
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85079152713&partnerID=8YFLogxK
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Accepted Version
dcterms.dateAccepted2020-02-11
rioxxterms.versionAM
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.urolonc.2020.01.010
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeEmbargoed


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