Impact of sex on response to neoadjuvant chemotherapy in patients with bladder cancer
dc.contributor.author | D'Andrea, David | |
dc.contributor.author | Black, Peter C. | |
dc.contributor.author | Zargar, Homayoun | |
dc.contributor.author | Zargar-Shoshtari, Kamran | |
dc.contributor.author | Zehetmayer, Sonja | |
dc.contributor.author | Fairey, Adrian S. | |
dc.contributor.author | Mertens, Laura S. | |
dc.contributor.author | Dinney, Colin P. | |
dc.contributor.author | Mir, Maria C. | |
dc.contributor.author | Krabbe, Laura Maria | |
dc.contributor.author | Cookson, Michael S. | |
dc.contributor.author | Jacobsen, Niels Erik | |
dc.contributor.author | Montgomery, Jeffrey S. | |
dc.contributor.author | Vasdev, Nikhil | |
dc.contributor.author | Yu, Evan Y. | |
dc.contributor.author | Xylinas, Evanguelos | |
dc.contributor.author | Campain, Nicholas J. | |
dc.contributor.author | Kassouf, Wassim | |
dc.contributor.author | Dall'Era, Marc A. | |
dc.contributor.author | Seah, Jo An | |
dc.contributor.author | Ercole, Cesar E. | |
dc.contributor.author | Horenblas, Simon | |
dc.contributor.author | Sridhar, Srikala S. | |
dc.contributor.author | McGrath, John S. | |
dc.contributor.author | Aning, Jonathan | |
dc.contributor.author | Wright, Jonathan L. | |
dc.contributor.author | Thorpe, Andrew C. | |
dc.contributor.author | Morgan, Todd M. | |
dc.contributor.author | Holzbeierlein, Jeffrey M. | |
dc.contributor.author | Bivalacqua, Trinity J. | |
dc.contributor.author | North, Scott | |
dc.contributor.author | Barocas, Daniel A. | |
dc.contributor.author | Lotan, Yair | |
dc.contributor.author | Grivas, Petros | |
dc.contributor.author | Stephenson, Andrew J. | |
dc.contributor.author | Shah, Jay B. | |
dc.contributor.author | van Rhijn, Bas W. | |
dc.contributor.author | Daneshmand, Siamak | |
dc.contributor.author | Spiess, Philippe E. | |
dc.contributor.author | Shariat, Shahrokh F. | |
dc.date.accessioned | 2020-05-20T00:10:46Z | |
dc.date.available | 2020-05-20T00:10:46Z | |
dc.date.issued | 2020-02-11 | |
dc.identifier.citation | D'Andrea , D , Black , P C , Zargar , H , Zargar-Shoshtari , K , Zehetmayer , S , Fairey , A S , Mertens , L S , Dinney , C P , Mir , M C , Krabbe , L M , Cookson , M S , Jacobsen , N E , Montgomery , J S , Vasdev , N , Yu , E Y , Xylinas , E , Campain , N J , Kassouf , W , Dall'Era , M A , Seah , J A , Ercole , C E , Horenblas , S , Sridhar , S S , McGrath , J S , Aning , J , Wright , J L , Thorpe , A C , Morgan , T M , Holzbeierlein , J M , Bivalacqua , T J , North , S , Barocas , D A , Lotan , Y , Grivas , P , Stephenson , A J , Shah , J B , van Rhijn , B W , Daneshmand , S , Spiess , P E & Shariat , S F 2020 , ' Impact of sex on response to neoadjuvant chemotherapy in patients with bladder cancer ' , Urologic Oncology: Seminars and Original Investigations . https://doi.org/10.1016/j.urolonc.2020.01.010 | |
dc.identifier.issn | 1078-1439 | |
dc.identifier.uri | http://hdl.handle.net/2299/22726 | |
dc.description | © 2020 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/. | |
dc.description.abstract | Objective: To assess the effect of patient's sex on response to neoadjuvant chemotherapy (NAC) in patients with clinically nonmetastatic muscle-invasive bladder cancer (MIBC). Methods: Complete pathologic response, defined as ypT0N0 at radical cystectomy, and downstaging were evaluated using sex-adjusted univariable and multivariable logistic regression modeling. We used interaction terms to account for age of menopause and smoking status. The association of sex with overall survival and cancer-specific survival was evaluated using Cox regression analyses. Results: A total of 1,031 patients were included in the analysis, 227 (22%) of whom were female. Female patients had a higher rate of extravesical disease extension (P = 0.01). After the administration of NAC, ypT stage was equally distributed between sexes (P = 0.39). On multivariable logistic regression analyses, there was no difference between the sexes or age of menopause with regards to ypT0N0 rates or downstaging (all P > 0.5). On Cox regression analyses, sex was associated with neither overall survival (hazard ratio 1.04, 95% confidence interval 0.75–1.45, P = 0.81) nor cancer-specific survival (hazard ratio 1.06, 95% confidence interval 0.71–1.58, P = 0.77). Conclusion: Our study generates the hypothesis that NAC equalizes the preoperative disparity in pathologic stage between males and females suggesting a possible differential response between sexes. This might be the explanation underlying the comparable survival outcomes between sexes despite females presenting with more advanced tumor stage. | en |
dc.format.extent | 478298 | |
dc.language.iso | eng | |
dc.relation.ispartof | Urologic Oncology: Seminars and Original Investigations | |
dc.subject | Bladder cancer | |
dc.subject | Neoadjuvant chemotherapy | |
dc.subject | Response | |
dc.subject | Sex | |
dc.subject | Oncology | |
dc.subject | Urology | |
dc.title | Impact of sex on response to neoadjuvant chemotherapy in patients with bladder cancer | en |
dc.contributor.institution | Extracellular Vesicle Research Unit | |
dc.contributor.institution | Basic and Clinical Science Unit | |
dc.contributor.institution | Centre for Health Services and Clinical Research | |
dc.contributor.institution | Department of Clinical and Pharmaceutical Sciences | |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Department of Clinical, Pharmaceutical and Biological Science | |
dc.description.status | Peer reviewed | |
dc.date.embargoedUntil | 2021-02-11 | |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85079152713&partnerID=8YFLogxK | |
rioxxterms.versionofrecord | 10.1016/j.urolonc.2020.01.010 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true |