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        Montmorency tart cherry (Prunus cerasus L.) acts as a calorie restriction mimetic that increases intestinal fat and lifespan in Caenorhabditis elegans

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        Author
        van de Klashorst, David
        van den Elzen, Amber
        Weeteling, Jasper
        Roberts, Michael
        Desai, Terun
        Bottoms, Lindsay
        Hughes, Samantha
        Attention
        2299/22875
        Abstract
        Montmorency Tart Cherries, MTC, (Prunus cerasus L.) possess a high anthocyanin content as well as one of the highest oxygen radical absorbance capacities of fruits at common habitual portion sizes. MTC have been shown to contribute to reducing plasma lipids, plasma glucose and fat mass in rats and strikingly, similar effects are observed in humans. However, there is a paucity of research examining the molecular mechanisms by which such MTC effects are induced. Here, we show that when exposed to MTC, Caenorhabditis elegans display an extension of lifespan, with a corresponding increase in fat content and increase in neuromuscular function. Using RNA interference, we have confirmed that MTC is likely to function via the Peroxisome Proliferator-Activated Receptor (PPAR) signalling pathway. Further, consumption of MTC alters the pharyngeal pumping rate of worms which provides encouraging evidence that MTC may be operating as a calorie restriction mimetic via metabolic pathways.
        Publication date
        2020-03-10
        Published in
        Journal of Functional Foods
        Published version
        https://doi.org/10.1016/j.jff.2020.103890
        License
        http://creativecommons.org/licenses/by-nc-nd/4.0/
        Other links
        http://hdl.handle.net/2299/22875
        Relations
        School of Life and Medical Sciences
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