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dc.contributor.authorvan de Klashorst, David
dc.contributor.authorvan den Elzen, Amber
dc.contributor.authorWeeteling, Jasper
dc.contributor.authorRoberts, Michael
dc.contributor.authorDesai, Terun
dc.contributor.authorBottoms, Lindsay
dc.contributor.authorHughes, Samantha
dc.date.accessioned2020-06-19T00:05:20Z
dc.date.available2020-06-19T00:05:20Z
dc.date.issued2020-03-10
dc.identifier.citationvan de Klashorst , D , van den Elzen , A , Weeteling , J , Roberts , M , Desai , T , Bottoms , L & Hughes , S 2020 , ' Montmorency tart cherry (Prunus cerasus L.) acts as a calorie restriction mimetic that increases intestinal fat and lifespan in Caenorhabditis elegans ' , Journal of Functional Foods .
dc.identifier.issn1756-4646
dc.identifier.otherPURE: 15324262
dc.identifier.otherPURE UUID: e5f4811f-3799-49d1-b7bd-9e000e1ad44d
dc.identifier.otherORCID: /0000-0001-8606-0458/work/75948811
dc.identifier.otherScopus: 85081273510
dc.identifier.urihttp://hdl.handle.net/2299/22875
dc.description.abstractMontmorency Tart Cherries, MTC, (Prunus cerasus L.) possess a high anthocyanin content as well as one of the highest oxygen radical absorbance capacities fruits at common habitual portion sizes. MTC have been shown to contribute to reducing plasma lipids, plasma glucose and fat mass in rats and strikingly, similar effects are observed in humans. However, there is a paucity of research examining the molecular mechanisms by which such MTC effects are induced. Here, we show that when exposed to MTC, Caenorhabditis elegans display an extension of lifespan, with a corresponding increase in fat content and increase in neuromuscular function. Using RNA interference, we have confirmed that MTC is likely to function via the Peroxisome Proliferator-Activated Receptor (PPAR) signalling pathway. Further, consumption of MTC alters the pharyngeal pumping rate of worms which provides encouraging evidence that MTC may be operating as a calorie restriction mimetic via metabolic pathways.en
dc.language.isoeng
dc.relation.ispartofJournal of Functional Foods
dc.titleMontmorency tart cherry (Prunus cerasus L.) acts as a calorie restriction mimetic that increases intestinal fat and lifespan in Caenorhabditis elegansen
dc.contributor.institutionDepartment of Psychology and Sports Sciences
dc.contributor.institutionCentre for Research in Psychology and Sport Sciences
dc.contributor.institutionSport, Health and Exercise
dc.contributor.institutionAdaptive Physiology and Functional Nutrition
dc.contributor.institutionHealth and Wellbeing
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionAgriculture, Veterinary and Food Sciences
dc.contributor.institutionWeight and Obesity Research Group
dc.contributor.institutionInternational Judo Research Unit: i-dojo
dc.description.statusPeer reviewed
dc.date.embargoedUntil2021-03-10
rioxxterms.versionAM
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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