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dc.contributor.authorvan de Klashorst, David
dc.contributor.authorvan den Elzen, Amber
dc.contributor.authorWeeteling, Jasper
dc.contributor.authorRoberts, Michael
dc.contributor.authorDesai, Terun
dc.contributor.authorBottoms, Lindsay
dc.contributor.authorHughes, Samantha
dc.date.accessioned2020-06-19T00:05:20Z
dc.date.available2020-06-19T00:05:20Z
dc.date.issued2020-03-10
dc.identifier.citationvan de Klashorst , D , van den Elzen , A , Weeteling , J , Roberts , M , Desai , T , Bottoms , L & Hughes , S 2020 , ' Montmorency tart cherry (Prunus cerasus L.) acts as a calorie restriction mimetic that increases intestinal fat and lifespan in Caenorhabditis elegans ' , Journal of Functional Foods , vol. 68 , 103890 . https://doi.org/10.1016/j.jff.2020.103890
dc.identifier.issn1756-4646
dc.identifier.otherORCID: /0000-0001-8606-0458/work/75948811
dc.identifier.otherORCID: /0000-0003-4632-3764/work/92337152
dc.identifier.urihttp://hdl.handle.net/2299/22875
dc.description.abstractMontmorency Tart Cherries, MTC, (Prunus cerasus L.) possess a high anthocyanin content as well as one of the highest oxygen radical absorbance capacities of fruits at common habitual portion sizes. MTC have been shown to contribute to reducing plasma lipids, plasma glucose and fat mass in rats and strikingly, similar effects are observed in humans. However, there is a paucity of research examining the molecular mechanisms by which such MTC effects are induced. Here, we show that when exposed to MTC, Caenorhabditis elegans display an extension of lifespan, with a corresponding increase in fat content and increase in neuromuscular function. Using RNA interference, we have confirmed that MTC is likely to function via the Peroxisome Proliferator-Activated Receptor (PPAR) signalling pathway. Further, consumption of MTC alters the pharyngeal pumping rate of worms which provides encouraging evidence that MTC may be operating as a calorie restriction mimetic via metabolic pathways.en
dc.format.extent2080840
dc.language.isoeng
dc.relation.ispartofJournal of Functional Foods
dc.subjectAnthocyanins
dc.subjectHealthy aging
dc.subjectLifespan
dc.subjectMetabolic Syndrome
dc.subjectPharyngeal pumping
dc.subjectPolyphenol
dc.subjectFood Science
dc.subjectMedicine (miscellaneous)
dc.subjectNutrition and Dietetics
dc.titleMontmorency tart cherry (Prunus cerasus L.) acts as a calorie restriction mimetic that increases intestinal fat and lifespan in Caenorhabditis elegansen
dc.contributor.institutionDepartment of Psychology and Sports Sciences
dc.contributor.institutionCentre for Research in Psychology and Sports
dc.contributor.institutionSport, Health and Exercise
dc.contributor.institutionAdaptive Physiology and Functional Nutrition
dc.contributor.institutionHealth and Wellbeing
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionAgriculture, Food and Veterinary Sciences
dc.contributor.institutionDepartment of Psychology, Sport and Geography
dc.contributor.institutionCentre for Applied Clinical, Health and Care Research (CACHE)
dc.contributor.institutionCentre for Future Societies Research
dc.contributor.institutionHigh Performance Sport Research Group
dc.contributor.institutionExercise, Health and Wellbeing Research Group
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85081273510&partnerID=8YFLogxK
rioxxterms.versionofrecord10.1016/j.jff.2020.103890
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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