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dc.contributor.authorGorog, Diana
dc.contributor.authorBecker, Richard
dc.date.accessioned2020-06-20T00:07:15Z
dc.date.available2020-06-20T00:07:15Z
dc.date.issued2020-06-11
dc.identifier.citationGorog , D & Becker , R 2020 , ' Point-of-care Platelet Function Tests: Relevance to Arterial Thrombosis and Opportunities for Improvement ' , Journal of Thrombosis and Thrombolysis . https://doi.org/10.1007/s11239-020-02170-z
dc.identifier.issn0929-5305
dc.identifier.otherPURE: 22079983
dc.identifier.otherPURE UUID: 78a2486b-46d3-46bf-a439-ffef11a0306b
dc.identifier.otherScopus: 85086429695
dc.identifier.urihttp://hdl.handle.net/2299/22894
dc.description© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
dc.description.abstractStudies using whole blood platelet aggregometry as a laboratory research tool, provided important insights into the mecha- nism and modulators of platelet aggregation. Subsequently, a number of point-of-care (POC) platelet function tests (PFTs) were developed for clinical use, based on the concept that an individual’s thrombotic profile could be assessed in vitro by assessing the response to stimulation of platelet aggregation by specific, usually solo agonists such as adenosine diphosphate (ADP), collagen and thrombin. However, adjusting antiplatelet medication in order to improve the results of such POC PFTs has not translated into a meaningful reduction in cardiovascular events, which may be attributable to important differences between the POC PFT techniques and in vivo conditions, including patient-to-patient variability. Important limitations of most tests include the use of citrate-anticoagulated blood. Citrate directly and irreversibly diminishes platelet function and even after recalcification, it may result in altered platelet aggregation in response to ADP, epinephrine or collagen, and inter- fere with thrombin generation from activated platelets. Furthermore, most tests do not employ flowing blood and therefore do not assess the effect of high shear forces on platelets that initiate, propagate and stabilize arterial thrombi. Finally, the effect of endogenous thrombolysis, due to fibrinolysis and dislodgement, which ultimately determines the outcome of a thrombotic stimulus, is mostly not assessed. In order to accurately reflect an individual’s predisposition to arterial thrombosis, future mbotic status which overcome these limitations should be used, to improve cardiovascular risk prediction and uide pharmacotherapy.en
dc.language.isoeng
dc.relation.ispartofJournal of Thrombosis and Thrombolysis
dc.rightsOpen
dc.titlePoint-of-care Platelet Function Tests: Relevance to Arterial Thrombosis and Opportunities for Improvementen
dc.contributor.institutionDepartment of Clinical and Pharmaceutical Sciences
dc.contributor.institutionCentre for Health Services and Clinical Research
dc.contributor.institutionBasic and Clinical Science Unit
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Clinical, Pharmaceutical and Biological Science
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2020-06-11
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1007/s11239-020-02170-z
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


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