dc.contributor.author | Kvavilashvili, Lia | |
dc.contributor.author | Niedzwienska, Agnieszka | |
dc.contributor.author | Gilbert, Sam | |
dc.contributor.author | Markostamou, Ioanna | |
dc.date.accessioned | 2020-06-21T00:15:19Z | |
dc.date.available | 2020-06-21T00:15:19Z | |
dc.date.issued | 2020-04 | |
dc.identifier.citation | Kvavilashvili , L , Niedzwienska , A , Gilbert , S & Markostamou , I 2020 , ' Deficits in Spontaneous Cognition as an Early Marker of Alzheimer’s Disease ' , Trends in Cognitive Sciences , vol. 24 , no. 4 , pp. 285-301 . https://doi.org/10.1016/j.tics.2020.01.005 | |
dc.identifier.issn | 1364-6613 | |
dc.identifier.other | ORCID: /0000-0001-7343-0122/work/128033145 | |
dc.identifier.uri | http://hdl.handle.net/2299/22899 | |
dc.description | © 2020 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/. | |
dc.description.abstract | In the absence of a pharmacological cure, finding the most sensitive early cognitive markers of Alzheimer's disease (AD) is becoming increasingly important. In this article we review evidence showing that brain mechanisms of spontaneous, but stimulus-dependent, cognition overlap with key hubs of the default mode network (DMN) that become compromised by amyloid pathology years before the clinical symptoms of AD. This leads to the formulation of a novel hypothesis which predicts that spontaneous, but stimulus-dependent, conscious retrieval processes, that are generally intact in healthy aging, will be particularly compromised in people at the earliest stages of AD. Initial evidence for this hypothesis is presented across diverse experimental paradigms (e.g., prospective memory, mind-wandering), and new avenues for research in this area are outlined. | en |
dc.format.extent | 17 | |
dc.format.extent | 1173802 | |
dc.language.iso | eng | |
dc.relation.ispartof | Trends in Cognitive Sciences | |
dc.subject | Default Mode Network | |
dc.subject | mind-wandering | |
dc.subject | Prospective memory | |
dc.subject | involuntary memory | |
dc.subject | spontaneous retrieval | |
dc.subject | mild cognitive impairment | |
dc.subject | posterior cingulate cortex | |
dc.subject | prospective memory | |
dc.subject | default mode network | |
dc.subject | Experimental and Cognitive Psychology | |
dc.subject | Neuropsychology and Physiological Psychology | |
dc.subject | Cognitive Neuroscience | |
dc.title | Deficits in Spontaneous Cognition as an Early Marker of Alzheimer’s Disease | en |
dc.contributor.institution | Department of Psychology and Sports Sciences | |
dc.contributor.institution | Psychology | |
dc.contributor.institution | Centre for Research in Psychology and Sports | |
dc.contributor.institution | Learning, Memory and Thinking | |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Department of Psychology, Sport and Geography | |
dc.contributor.institution | Cognitive Neuropsychology | |
dc.description.status | Peer reviewed | |
dc.date.embargoedUntil | 2021-02-23 | |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85079880386&partnerID=8YFLogxK | |
rioxxterms.versionofrecord | 10.1016/j.tics.2020.01.005 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |