dc.contributor.author | Inal, Jameel M. | |
dc.date.accessioned | 2020-07-09T00:08:05Z | |
dc.date.available | 2020-07-09T00:08:05Z | |
dc.date.issued | 2020-06-16 | |
dc.identifier.citation | Inal , J M 2020 , ' Decoy ACE2-expressing extracellular vesicles that competitively bind SARS-CoV-2 as a possible COVID-19 therapy ' , Clinical science (London, England : 1979) , vol. 134 , no. 12 , pp. 1301-1304 . https://doi.org/10.1042/CS20200623 | |
dc.identifier.issn | 0143-5221 | |
dc.identifier.uri | http://hdl.handle.net/2299/22950 | |
dc.description | © 2020 The Author(s). This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND - https://creativecommons.org/licenses/by-nc-nd/4.0/). | |
dc.description.abstract | The novel strain of coronavirus that appeared in 2019, SARS-CoV-2, is the causative agent of severe respiratory disease, COVID-19, and the ongoing pandemic. As for SARS-CoV that caused the SARS 2003 epidemic, the receptor on host cells that promotes uptake, through attachment of the spike (S) protein of the virus, is angiotensin-converting enzyme 2 (ACE2). In a recent article published by Batlle et al. (Clin. Sci. (Lond.) (2020) 134, 543-545) it was suggested that soluble recombinant ACE2 could be used as a novel biological therapeutic to intercept the virus, limiting the progression of infection and reducing lung injury. Another way, discussed here, to capture SARS-CoV-2, as an adjunct or alternative, would be to use ACE2+-small extracellular vesicles (sEVs). A competitive inhibition therapy could therefore be developed, using sEVs from engineered mesenchymal stromal/stem cells (MSCs), overexpressing ACE2. | en |
dc.format.extent | 4 | |
dc.format.extent | 463414 | |
dc.language.iso | eng | |
dc.relation.ispartof | Clinical science (London, England : 1979) | |
dc.subject | ARDS | |
dc.subject | competitive inhibition therapy | |
dc.subject | COVID-19 | |
dc.subject | Extracellular Vesicles | |
dc.subject | SARS-CoV-2 | |
dc.subject | Medicine(all) | |
dc.title | Decoy ACE2-expressing extracellular vesicles that competitively bind SARS-CoV-2 as a possible COVID-19 therapy | en |
dc.contributor.institution | Biosciences Research Group | |
dc.description.status | Peer reviewed | |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85086625666&partnerID=8YFLogxK | |
rioxxterms.versionofrecord | 10.1042/CS20200623 | |
rioxxterms.type | Other | |
herts.preservation.rarelyaccessed | true | |