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        Acceptability in the Older Population: The Importance of an Appropriate Tablet Size

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        Author
        Vallet, Thibault
        Michelon , Hugues
        Orlu, Mine
        Jani, Yogini Hariprasad
        Leglise , Patrick
        Laribe-Caget , Sandra
        Piccoli, Matthieu
        Le Fur , Aurélie
        Liu, Fang
        Ruiz , Fabrice
        Boudy , Vincent
        Attention
        2299/23071
        Abstract
        Presenting many advantages, solid oral dosage forms (SODFs) are widely manufactured and frequently prescribed in older populations regardless of the specific characteristics of patients. Commonly, patients with dysphagia (swallowing disorders) experience difficulties taking SODFs, which may lead to non-adherence or misuse. SODF characteristics (e.g., size, shape, thickness) are likely to influence swallowability. Herein, we used the acceptability reference framework (the ClinSearch acceptability score test (CAST))—a 3D-map juxtaposing two acceptability profiles—to investigate the impact of tablet size on acceptability. We collected 938 observer reports on the tablet intake by patients ≥ 65 y in hospitals or care homes. As we might expect, tablets could be classified as accepted in older patients without dysphagia (n = 790), while not in those with swallowing disorders (n = 146). However, reducing the tablet size had a significant impact on acceptability in this subpopulation: tablets < 6.5 mm appeared to be accepted by patients with swallowing disorders. Among the 309 distinct tablets assessed in this study, ranging in size from 4.7 to 21.5 mm, 83% are ≥ 6.5 mm and consequently may be poorly accepted by institutionalized older people and older inpatients suffering from dysphagia. This underlines the need to develop and prescribe medicines with the best adapted characteristics to reach an optimal acceptability in targeted users.
        Publication date
        2020-08-08
        Published in
        Pharmaceutics
        Published version
        https://doi.org/10.3390/pharmaceutics12080746
        License
        http://creativecommons.org/licenses/by/4.0/
        Other links
        http://hdl.handle.net/2299/23071
        Relations
        School of Life and Medical Sciences
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