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dc.contributor.authorGaba, F.
dc.contributor.authorBlyuss, O.
dc.contributor.authorChandrasekaran, D.
dc.contributor.authorOsman, M.
dc.contributor.authorGoyal, S.
dc.contributor.authorGan, C.
dc.contributor.authorIzatt, L.
dc.contributor.authorTripathi, V.
dc.contributor.authorEsteban, I.
dc.contributor.authorMcNicol, L.
dc.contributor.authorRagupathy, K.
dc.contributor.authorCrawford, R.
dc.contributor.authorEvans, D. G.
dc.contributor.authorLegood, R.
dc.contributor.authorMenon, U.
dc.contributor.authorManchanda, R.
dc.date.accessioned2020-08-28T00:07:24Z
dc.date.available2020-08-28T00:07:24Z
dc.date.issued2020-08-16
dc.identifier.citationGaba , F , Blyuss , O , Chandrasekaran , D , Osman , M , Goyal , S , Gan , C , Izatt , L , Tripathi , V , Esteban , I , McNicol , L , Ragupathy , K , Crawford , R , Evans , D G , Legood , R , Menon , U & Manchanda , R 2020 , ' Attitudes towards risk-reducing early salpingectomy with delayed oophorectomy for ovarian cancer prevention : a cohort study ' , BJOG: An International Journal of Obstetrics and Gynaecology , vol. 2020 , 1471-0528.16424 . https://doi.org/10.1111/1471-0528.16424
dc.identifier.issn1470-0328
dc.identifier.otherPURE: 22542814
dc.identifier.otherPURE UUID: 6eef54a0-2628-4995-9c40-1a8b7b1f71be
dc.identifier.otherScopus: 85089443497
dc.identifier.otherORCID: /0000-0002-0194-6389/work/79522462
dc.identifier.urihttp://hdl.handle.net/2299/23085
dc.description.abstractObjective: To determine risk-reducing early salpingectomy and delayed oophorectomy (RRESDO) acceptability and effect of surgical prevention on menopausal sequelae/satisfaction/regret in women at increased ovarian cancer (OC) risk. Design: Multicentre, cohort, questionnaire study (IRSCTN:12310993). Setting: United Kingdom (UK). Population: UK women without OC ≥18 years, at increased OC risk, with/without previous RRSO, ascertained through specialist familial cancer/genetic clinics and BRCA support groups. Methods: Participants completed a 39-item questionnaire. Baseline characteristics were described using descriptive statistics. Logistic/linear regression models analysed the impact of variables on RRESDO acceptability and health outcomes. Main outcomes: RRESDO acceptability, menopausal sequelae, satisfaction/regret. Results: In all, 346 of 683 participants underwent risk-reducing salpingo-oophorectomy (RRSO). Of premenopausal women who had not undergone RRSO, 69.1% (181/262) found it acceptable to participate in a research study offering RRESDO. Premenopausal women concerned about sexual dysfunction were more likely to find RRESDO acceptable (odds ratio [OR] = 2.9, 95% CI 1.2–7.7, P = 0.025). Women experiencing sexual dysfunction after premenopausal RRSO were more likely to find RRESDO acceptable in retrospect (OR = 5.3, 95% CI 1.2–27.5, P < 0.031). In all, 88.8% (143/161) premenopausal and 95.2% (80/84) postmenopausal women who underwent RRSO, respectively, were satisfied with their decision, whereas 9.4% (15/160) premenopausal and 1.2% (1/81) postmenopausal women who underwent RRSO regretted their decision. HRT uptake in premenopausal individuals without breast cancer (BC) was 74.1% (80/108). HRT use did not significantly affect satisfaction/regret levels but did reduce symptoms of vaginal dryness (OR = 0.4, 95% CI 0.2–0.9, P = 0.025). Conclusion: Data show high RRESDO acceptability, particularly in women concerned about sexual dysfunction. Although RRSO satisfaction remains high, regret rates are much higher for premenopausal women than for postmenopausal women. HRT use following premenopausal RRSO does not increase satisfaction but does reduce vaginal dryness. Tweetable abstract: RRESDO has high acceptability among premenopausal women at increased ovarian cancer risk, particularly those concerned about sexual dysfunction.en
dc.language.isoeng
dc.relation.ispartofBJOG: An International Journal of Obstetrics and Gynaecology
dc.subjectAcceptability
dc.subjectBRCA
dc.subjectovarian cancer
dc.subjectrisk-reducing early salpingectomy with delayed oophorectomy
dc.subjectObstetrics and Gynaecology
dc.titleAttitudes towards risk-reducing early salpingectomy with delayed oophorectomy for ovarian cancer prevention : a cohort studyen
dc.contributor.institutionSchool of Physics, Astronomy and Mathematics
dc.contributor.institutionDepartment of Pharmacy, Pharmacology and Postgraduate Medicine
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85089443497&partnerID=8YFLogxK
dc.identifier.urlhttps://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1111/1471-0528.16424
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1111/1471-0528.16424
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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