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        Survival Outcomes After High-dose Chemotherapy and Stem Cell Transplantation in the Salvage Setting for Relapsed or Refractory Germ Cell Cancers

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        3675.full.pdf (PDF, 106Kb)
        Author
        Sharma, Anand
        Babra, Deshveer
        Joshi, Priya
        Hall, Marcia
        Gogbashian, Andrew
        Vasdev, Nikhil
        Joseph, Magdalene
        Yazdan, Amir
        Kanfer, Edward
        Attention
        2299/23525
        Abstract
        Background/Aim: High-dose chemotherapy (HDCT) and stem cell transplantation (SCT) have been established as the standard of care in patients with relapsed germ cell tumours (GCTs). We evaluated the safety, efficacy and tolerability of HDCT/ SCT in patients with relapsed GCTs. Patients and Methods: Twenty-eight patients with relapsed GCTs, treated with HDCT, were included in this study. The conditioning regime was carboplatin, etoposide, cyclophosphamide and paclitaxel. Clinical, radiological imaging and tumour markers determined treatment outcomes. Results: Median age was 35 years (range=21-57 years) with 26 males and 2 females. Median time to first relapse was 6 months. Median time to progression after 2nd line chemotherapy was 17.3 months. Fourteen patients had peripheral neurotoxicity (≥Grade 2) (50%), 4 patients developed renal failure, 5 had ototoxicity (≥Grade 2) and 1 patient developed acute myeloid leukaemia. Median survival was 62 months and 16 patients (57%) are in clinical follow-up with surveillance. Conclusion: In relapsed GCT patients, median survival may exceed 5 years post-HDCT and SCT.
        Publication date
        2020-11
        Published in
        In VIVO - International Journal of Experimental and Clinical Pathophysiology and Drug Research
        Published version
        https://doi.org/10.21873/invivo.12215
        Other links
        http://hdl.handle.net/2299/23525
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