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dc.contributor.authorEmin Cam, Muhammet
dc.contributor.authorNur Hazar-Yavuz, Ayse
dc.contributor.authorCesur, Sumeyye
dc.contributor.authorOzkan, Ozan
dc.contributor.authorAlenezi, Hussain
dc.contributor.authorTurkoglu Sasmazel, Hilal
dc.contributor.authorSayip Eroglu, Mehmet
dc.contributor.authorBrako, Francis
dc.contributor.authorAhmed, Jubair
dc.contributor.authorKabasakal, Levent
dc.contributor.authorRen, Guogang
dc.contributor.authorGunduz, Oguzhan
dc.contributor.authorEdirisinghe, Mohan
dc.date.accessioned2021-01-08T14:15:02Z
dc.date.available2021-01-08T14:15:02Z
dc.date.issued2020-10-15
dc.identifier.citationEmin Cam , M , Nur Hazar-Yavuz , A , Cesur , S , Ozkan , O , Alenezi , H , Turkoglu Sasmazel , H , Sayip Eroglu , M , Brako , F , Ahmed , J , Kabasakal , L , Ren , G , Gunduz , O & Edirisinghe , M 2020 , ' A novel treatment strategy for preterm birth: Intra-vaginal progesterone-loaded fibrous patches ' , International Journal of Pharmaceutics , vol. 588 , 119782 . https://doi.org/10.1016/j.ijpharm.2020.119782
dc.identifier.issn0378-5173
dc.identifier.otherPURE: 22550000
dc.identifier.otherPURE UUID: ed55c28c-7761-4293-82b2-50c91068262d
dc.identifier.otherPubMed: 32822780
dc.identifier.otherScopus: 85089830531
dc.identifier.otherORCID: /0000-0001-8865-1526/work/86488709
dc.identifier.urihttp://hdl.handle.net/2299/23656
dc.description© 2020 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/.
dc.description.abstractProgesterone-loaded poly(lactic) acid fibrous polymeric patches were produced using electrospinning and pressurized gyration for intra-vaginal application to prevent preterm birth. The patches were intravaginally inserted into rats in the final week of their pregnancy, equivalent to the third trimester of human pregnancy. Maintenance tocolysis with progesterone-loaded patches was elucidated by recording the contractile response of uterine smooth muscle to noradrenaline in pregnant rats. Both progesterone-loaded patches indicated similar results from release and thermal studies, however, patches obtained by electrospinning had smaller average diameters and more uniform dispersion compared to pressurized gyration. Patches obtained by pressurized gyration had better results in production yield and tensile strength than electrospinning; thereby pressurized gyration is better suited for scaled-up production. The patches did not affect cell attachment, viability, and proliferation on Vero cells negatively. Consequently, progesterone-loaded patches are a novel and successful treatment strategy for preventing preterm birth.en
dc.format.extent15
dc.language.isoeng
dc.relation.ispartofInternational Journal of Pharmaceutics
dc.rightsEmbargoed
dc.subjectElectrospinning
dc.subjectFibers
dc.subjectPolymeric patch
dc.subjectPressurized gyration
dc.subjectPreterm birth
dc.subjectProgesterone
dc.subjectPharmaceutical Science
dc.titleA novel treatment strategy for preterm birth: Intra-vaginal progesterone-loaded fibrous patchesen
dc.contributor.institutionDepartment of Engineering and Technology
dc.contributor.institutionSchool of Physics, Engineering & Computer Science
dc.contributor.institutionBioEngineering
dc.contributor.institutionMaterials and Structures
dc.contributor.institutionCentre for Engineering Research
dc.description.statusPeer reviewed
dc.date.embargoedUntil2021-08-19
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85089830531&partnerID=8YFLogxK
dc.identifier.urlhttps://discovery.ucl.ac.uk/id/eprint/10108902
dc.relation.schoolSchool of Physics, Engineering & Computer Science
dc.description.versiontypeFinal Accepted Version
dcterms.dateAccepted2020-10-15
rioxxterms.versionAM
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.ijpharm.2020.119782
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeEmbargoed


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