dc.contributor.author | Mansfield, Edward D.H. | |
dc.contributor.author | Filippov, Sergey K. | |
dc.contributor.author | de la Rosa, Victor R. | |
dc.contributor.author | Cook, Michael T. | |
dc.contributor.author | Grillo, Isabelle | |
dc.contributor.author | Hoogenboom, Richard | |
dc.contributor.author | Williams, Adrian C. | |
dc.contributor.author | Khutoryanskiy, Vitaliy V. | |
dc.date.accessioned | 2021-02-01T12:30:03Z | |
dc.date.available | 2021-02-01T12:30:03Z | |
dc.date.issued | 2021-05-15 | |
dc.identifier.citation | Mansfield , E D H , Filippov , S K , de la Rosa , V R , Cook , M T , Grillo , I , Hoogenboom , R , Williams , A C & Khutoryanskiy , V V 2021 , ' Understanding the temperature induced aggregation of silica nanoparticles decorated with temperature-responsive polymers: can a small step in the chemical structure make a giant leap for a phase transition? ' , Journal of Colloid and Interface Science , vol. 590 , pp. 249-259 . https://doi.org/10.1016/j.jcis.2021.01.044 | |
dc.identifier.issn | 0021-9797 | |
dc.identifier.other | RIS: urn:AC2BD0F02AA3D0B2861715009FEED0A6 | |
dc.identifier.other | RIS: urn:AC2BD0F02AA3D0B2861715009FEED0A6 | |
dc.identifier.uri | http://hdl.handle.net/2299/23830 | |
dc.description | © 2021 Elsevier Inc. All rights reserved. This is the accepted manuscript version of an article which has been published in final form at: https://doi.org/10.1016/j.jcis.2021.01.044 | |
dc.description.abstract | Temperature-responsive nanomaterials have gained increasing interest over the past decade due their ability to undergo conformational changes in situ, in response to a change in temperature. One class of temperature-responsive polymers are those with lower critical solution temperature, which phase separate in aqueous solution above a critical temperature. When these temperature-responsive polymers are grafted to a solid nanoparticle, a change in their surface properties occurs above this critical temperature, from hydrophilic to more hydrophobic, giving them a propensity to aggregate. This study explores the temperature induced aggregation of silica nanoparticles functionalised with two isomeric temperature-responsive polymers with lower critical solution temperature (LCST) behavior, namely poly(N-isopropyl acrylamide) (PNIPAM), and poly(2-n-propyl-2-oxazoline) (PNPOZ) with similar molecular weights (5,000 Da) and grafting density. These nanoparticles exhibited striking differences in the temperature of aggregation, which is consistent with LCST of each polymer. Using a combination of small-angle neutron scattering (SANS) and dynamic light scattering (DLS), we probed subtle differences in the aggregation mechanism for PNIPAM- and PNPOZ-decorated silica nanoparticles. The nanoparticles decorated with PNIPAM and PNPOZ show similar aggregation mechanism that was independent of polymer structure, whereby aggregation starts by the formation of small aggregates. A further increase in temperature leads to interaction between these aggregates and results in full-scale aggregation and subsequent phase separation. | en |
dc.format.extent | 11 | |
dc.format.extent | 882163 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Colloid and Interface Science | |
dc.subject | Silica nanoparticles | |
dc.subject | Aggregation | |
dc.subject | SANS | |
dc.subject | temperature-responsive polymers | |
dc.subject | PNIPAM | |
dc.subject | poly(2-oxazoline) | |
dc.subject | Poly(2-oxazoline) | |
dc.subject | Temperature-responsive polymers | |
dc.subject | Electronic, Optical and Magnetic Materials | |
dc.subject | Surfaces, Coatings and Films | |
dc.subject | Biomaterials | |
dc.subject | Colloid and Surface Chemistry | |
dc.title | Understanding the temperature induced aggregation of silica nanoparticles decorated with temperature-responsive polymers: can a small step in the chemical structure make a giant leap for a phase transition? | en |
dc.contributor.institution | Centre for Research into Topical Drug Delivery and Toxicology | |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Department of Clinical, Pharmaceutical and Biological Science | |
dc.description.status | Peer reviewed | |
dc.date.embargoedUntil | 2022-01-27 | |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85100422359&partnerID=8YFLogxK | |
rioxxterms.versionofrecord | 10.1016/j.jcis.2021.01.044 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |