dc.contributor.author | Bading-Taika, Bayissi | |
dc.contributor.author | Souza, Alain | |
dc.contributor.author | Bourobou Bourobou, Henri-Paul | |
dc.contributor.author | Lione, Lisa | |
dc.date.accessioned | 2021-02-05T14:14:00Z | |
dc.date.available | 2021-02-05T14:14:00Z | |
dc.date.issued | 2020-08-25 | |
dc.identifier.citation | Bading-Taika , B , Souza , A , Bourobou Bourobou , H-P & Lione , L 2020 , ' Hypoglycaemic and anti-hyperglycaemic activity of Tabernanthe iboga aqueous extract in fructose-fed Streptozotocin type 2 diabetic rats ' , Advances in Traditional Medicine . https://doi.org/10.1007/s13596-020-00484-0 | |
dc.identifier.issn | 2662-4052 | |
dc.identifier.other | ORCID: /0000-0002-5586-2578/work/127010389 | |
dc.identifier.uri | http://hdl.handle.net/2299/23848 | |
dc.description | Publisher Copyright: © 2020, Institute of Korean Medicine, Kyung Hee University. This is a post-peer-review, pre-copyedit version of Bading-Taïka, B., Souza, A., Bourobou Bourobou, HP. et al. Hypoglycaemic and anti-hyperglycaemic activity of Tabernanthe iboga aqueous extract in fructose-fed streptozotocin type 2 diabetic rats. ADV TRADIT MED (ADTM) (2020). https://doi.org/10.1007/s13596-020-00484-0 | |
dc.description.abstract | Root bark preparations of the Gabonese plant Tabernanthe iboga (T. iboga) has long been used in traditional medicine in Central and West African regions for the management of type 2 diabetes (T2D). This study is the first investigation of in vivo hypoglycaemic activity in healthy rats and anti-hyperglycaemic activity of T. iboga in a 10% fructose-fed (40 mg/kg i.p.) streptozotocin (STZ) injected type 2 diabetic rat model. T. iboga at 50 to 200 mg/kg induced hypoglycaemia activity over 3 h fasted glucose tolerance in healthy Wistar rats and anti-hyperglycaemic effects on non-fasted and fasted blood glucose in fructose-fed STZ T2D rats with no toxicity. Fructose-fed STZ T2D rats developed characteristic type 2 diabetic complications over 6 weeks exhibiting significantly elevated fasting and non-fasting blood glucose, polydipsia, reduced body weight gain and glucose and insulin tolerance compared with STZ alone and normal control rats. T. iboga (50 mg/kg and 200 mg/kg bw) administered p.o. once daily for 4 weeks significantly improved diabetic symptoms of polydipsia, reduced body weight, hyperglycaemia, glucose and insulin tolerance (as AUC) compared with fructose-fed STZ T2D rats. T. iboga aqueous extract (50 mg/kg and 200 mg/kg) also significantly reversed altered actions of marker enzymes of liver including alkaline phosphatase (ALP), alanine transaminase (ALT), aspartate transaminase (AST), creatinine, HbA1c and elevated triglycerides in fructose-fed STZ type 2 diabetic rats. Our outcomes show that daily oral provision of T. iboga improves type 2 diabetes complications, superior to glibenclamide, in rat fructose-fed STZ model and offers the potential for safe clinical management of T2D in Gabon. | en |
dc.format.extent | 1372729 | |
dc.language.iso | eng | |
dc.relation.ispartof | Advances in Traditional Medicine | |
dc.subject | Anti-hyperglycaemic activity | |
dc.subject | Gabon | |
dc.subject | Hypoglycaemic activity | |
dc.subject | Medicinal plant | |
dc.subject | Tabernanthe iboga | |
dc.subject | Type 2 diabetes mellitus | |
dc.subject | Complementary and alternative medicine | |
dc.title | Hypoglycaemic and anti-hyperglycaemic activity of Tabernanthe iboga aqueous extract in fructose-fed Streptozotocin type 2 diabetic rats | en |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Centre for Health Services and Clinical Research | |
dc.contributor.institution | Basic and Clinical Science Unit | |
dc.contributor.institution | TRP Ion channels | |
dc.contributor.institution | Department of Clinical, Pharmaceutical and Biological Science | |
dc.contributor.institution | Centre for Research in Mechanisms of Disease and Drug Discovery | |
dc.description.status | Peer reviewed | |
dc.date.embargoedUntil | 2021-08-25 | |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85089864428&partnerID=8YFLogxK | |
rioxxterms.versionofrecord | 10.1007/s13596-020-00484-0 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |