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        Role, laboratory assessment and clinical relevance of fibrin, factor XIII and endogenous fibrinolysis in arterial and venous thrombosis

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        ijms_22_01472.pdf (PDF, 755Kb)
        Author
        Memtsas, Vassilios
        Arachchillage, Deepa RJ
        Gorog, Diana
        Attention
        2299/23862
        Abstract
        Diseases such as myocardial infarction, ischaemic stroke, peripheral vascular disease and venous thromboembolism are major contributors to morbidity and mortality. Procoagulant, anticoagu-lant and fibrinolytic pathways are finely regulated in healthy individuals and dysregulated procoagulant, anticoagulant and fibrinolytic pathways lead to arterial and venous thrombosis. In this review article, we discuss the (patho)physiological role and laboratory assessment of fibrin, factor XIII and endogenous fibrinolysis, which are key players in the terminal phase of the co-agulation cascade and fibrinolysis. Finally, we present the most up-to-date evidence for their involvement in various disease states and assessment of cardiovascular risk.
        Publication date
        2021-02-02
        Published in
        International Journal of Molecular Sciences
        Published version
        https://doi.org/10.3390/ijms22031472
        Other links
        http://hdl.handle.net/2299/23862
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