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dc.contributor.authorBridger, Joanna M
dc.contributor.authorFoster, Helen
dc.contributor.editorIourov, Ivan
dc.contributor.editorYurov, Yuri
dc.contributor.editorVorsanova, Svetlana
dc.date.accessioned2021-02-19T11:30:04Z
dc.date.available2021-02-19T11:30:04Z
dc.date.issued2020
dc.identifier.citationBridger , J M & Foster , H 2020 , Senescence and the Genome . in I Iourov , Y Yurov & S Vorsanova (eds) , Human Interphase Chromosomes : Biomedical Aspects . 2nd edn , Springer , Switzerland , pp. 87-106 . https://doi.org/10.1007/978-3-030-62532-0_5
dc.identifier.isbn9783030625313
dc.identifier.isbn9783030625320
dc.identifier.otherPURE: 24657286
dc.identifier.otherPURE UUID: 44d9b7e6-44e7-4fb7-9223-7ef515236f65
dc.identifier.otherORCID: /0000-0001-6553-4562/work/89119050
dc.identifier.urihttp://hdl.handle.net/2299/23925
dc.description© Springer Nature Switzerland AG 2020. This is the accepted manuscript version of a book chapter which has been published in final form at https://doi.org/10.1007/978-3-030-62532-0_5.
dc.description.abstractCellular senescence is commonly initiated in response to replicative or cell stress pathways. Senescent cells remain in a state of permanent cell cycle arrest and although being metabolically active, they exhibit distinct senescence phenotypes. Though cellular senescence may be beneficial in tumour suppression and wound healing, it is commonly associated with age-related diseases. There are various mechanisms and drivers that contribute to ageing, but it is becoming increasing apparent that processes related to chromatin and the epigenome are also important. Indeed, three of the nine hallmarks of ageing are genome specific including: genomic instability, epigenetic alterations and telomere attrition. With the advent of new technologies like DNA adenine methyltransferase identification and chromosome conformation capture, the features and complexity of the ageing genome are being revealed. This chapter will address key characteristics of interphase nuclei during cellular senescence including the spatio-temporal organisation of chromosomes, chromatin remodelling and epigenome changes.en
dc.format.extent19
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofHuman Interphase Chromosomes
dc.subjectSenescence
dc.subjectEpigenome
dc.subjectGenomic instability
dc.subjectTelomeres
dc.subjectNuclear Lamina
dc.subjectProgeroid syndromes
dc.titleSenescence and the Genomeen
dc.contributor.institutionBiosciences Research Group
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Clinical, Pharmaceutical and Biological Science
dc.date.embargoedUntil2022-01-01
rioxxterms.versionAM
rioxxterms.versionAM
rioxxterms.versionofrecordhttps://doi.org/10.1007/978-3-030-62532-0_5
rioxxterms.typeOther
herts.preservation.rarelyaccessedtrue


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