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        Ethnic Difference of Thrombogenicity in Patients with Cardiovascular Disease: A Pandora Box to Explain Prognostic Differences

        Author
        Kim, Hyun Kuk
        Tantry, Udaya S.
        Park, Hyun-Woong
        Geisler, Tobias
        Gorog, Diana
        Gurbel, Paul A
        Jeong, Young-Hoon
        Attention
        2299/24029
        Abstract
        Arterial and venous atherothrombotic events are finely regulated processes involving acomplex interplay between vulnerable blood, vulnerable vessel, and blood stasis.Vulnerable blood (‘thrombogenicity’) comprises complex interactions between cellularcomponents and plasma factors (inflammatory, procoagulant, anticoagulant, andfibrinolytic factors). The extent of thrombogenicity may determine the progression ofatheroma and the clinical manifestation of atherothrombotic events, with the highestthrombogenicity in African Americans and lowest in East Asians. Inherentthrombogenicity may influence clinical efficacy and safety of specific antithrombotictreatments in high-risk patients, which may in part explain the observation that EastAsians have reduced anti-ischemic benefits and elevated bleeding risk withantithrombotic therapy compared with Caucasians. In this review, we discuss availableevidence regarding the racial differences in thrombogenicity and its impact on clinicaloutcomes in patients with cardiovascular disease.
        Publication date
        2021-03-01
        Published in
        Korean Circulation Journal
        Published version
        https://doi.org/10.4070/kcj.2020.0537
        Other links
        http://hdl.handle.net/2299/24029
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