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dc.contributor.authorConnolly, Michael L.
dc.contributor.authorTzounis, Xenofon
dc.contributor.authorTuohy, Kieran M.
dc.contributor.authorLovegrove, Julie A.
dc.identifier.citationConnolly , M L , Tzounis , X , Tuohy , K M & Lovegrove , J A 2016 , ' Hypocholesterolemic and prebiotic effects of a whole-grain oat-based granola breakfast cereal in a cardio-metabolic "at risk" population ' , Frontiers in Microbiology , vol. 7 , no. November 2016 , 1675 .
dc.identifier.otherPURE: 14922150
dc.identifier.otherPURE UUID: 74d18efa-88bf-4aac-8eb6-006ae127dea3
dc.identifier.otherScopus: 85006750971
dc.identifier.otherORCID: /0000-0002-6776-2240/work/62751138
dc.description© 2016 Connolly, Tzounis, Tuohy and Lovegrove. This is an open-access article distributed under the terms of the Creative Commons Attribution License - CC BY (
dc.description.abstractMeta-analyses of randomized controlled trials (RTC) have confirmed the hypocholesterolaemic effect of oats and oat based fibers. However, the mechanisms by which oats or oat fractions lower cholesterol is not totally clear. Recognizing the important role of the gut microbiome in metabolism and metabolic disease risk, we examined the impact of whole grain oat Granola (WGO) on the human gut microbiota and cardio-metabolic risk factors using a randomized crossover dietary intervention in at risk individuals ( Identifier: NCT01925365). We randomized 32 individuals at risk of developing cardio-metabolic disease by virtue of mild hypercholesterolaemia or glucose intolerance, into two groups consuming either 45 g of WGO or non-whole grain (NWG) breakfast cereals daily for two 6-week intervention periods separated by a 4-week wash out period in a randomized, controlled, crossover, double-blinded design. Confirming the cholesterol lowering effect of WGO, we observed a significant time by treatment interaction, for total cholesterol (TC) (P = 0.0001) and LDL-cholesterol (LDL-C) (P = 0.02) compared to NWG. A significant time by treatment interaction was also observed for the relative abundance of fecal bifidobacteria (P = 0.0001), lactobacilli (P = 0.001) and total bacterial count (P = 0.008), which were all elevated after consumption of WGO. Daily consumption of WGO resulted in a prebiotic effect on the human gut microbiota composition and significant reductions in TC and LDL-C concentrations. Prebiotic modulation of the human gut microbiota may thus constitute a previously unrecognized mechanism contributing to the hypocholesterolaemic effects of whole grain oat Granola.en
dc.relation.ispartofFrontiers in Microbiology
dc.subjectCardiovascular risk
dc.subjectWhole-grain oat granola
dc.subjectMicrobiology (medical)
dc.titleHypocholesterolemic and prebiotic effects of a whole-grain oat-based granola breakfast cereal in a cardio-metabolic "at risk" populationen
dc.contributor.institutionDepartment of Clinical, Pharmaceutical and Biological Science
dc.contributor.institutionSchool of Life and Medical Sciences
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

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