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dc.contributor.authorKopsch, Thomas
dc.contributor.authorMurnane, Darragh
dc.contributor.authorSymons, Digby
dc.date.accessioned2021-03-13T19:00:01Z
dc.date.available2021-03-13T19:00:01Z
dc.date.issued2019-08-01
dc.identifier.citationKopsch , T , Murnane , D & Symons , D 2019 , ' Development of an adaptive bypass element for passive entrainment flow control in dry powder inhalers ' , Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science , vol. 233 , no. 15 , pp. 5201-5213 . https://doi.org/10.1177/0954406219845416
dc.identifier.issn0954-4062
dc.identifier.urihttp://hdl.handle.net/2299/24096
dc.description© IMechE 2019. This is the accepted manuscript version of an article which has been published in final form at https://doi.org/10.1177/0954406219845416
dc.description.abstractThe release of drug from dry powder inhalers is strongly dependent on the patient's inhalation profile. To maximise the effect of the treatment, it is necessary to optimise dry powder inhalers to achieve drug delivery that (A) is independent of the inhalation manoeuvre and (B) is targeted to the correct site in the lung. The purpose of this study is to develop a dry powder inhaler with an adaptive bypass element that achieves desired drug delivery behaviour. Computational and experimental methods are used. First, the effect of a generic variable bypass element on entrainment behaviour is modelled. This is done by modelling a dry powder inhaler as a network of flow. Second, the behaviour of a potential variable bypass element, a flap valve, is studied both computationally and experimentally. Third, the flow resistances are optimised to achieve consistent and desired entrainment behaviour for patients with very different inhalation manoeuvres. A simulated dry powder inhaler device design was found that achieves an approximately constant entrainment flow rate of 12 L/min when total flow rates larger than 20 L/min are applied. The developed dry powder inhaler is predicted to accurately deliver drug for patients with highly different inhalation manoeuvres.en
dc.format.extent13
dc.format.extent7103043
dc.language.isoeng
dc.relation.ispartofProceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science
dc.subjectBypass
dc.subjectdry powder inhaler
dc.subjectentrainment
dc.subjectflow control
dc.subjectoptimisation
dc.subjectMechanical Engineering
dc.titleDevelopment of an adaptive bypass element for passive entrainment flow control in dry powder inhalersen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85065387463&partnerID=8YFLogxK
rioxxterms.versionofrecord10.1177/0954406219845416
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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