Opioid painkillers' dependence in a sample of elderly medical inpatients

Abstract

BACKGROUND: Over the past few years there has been a growing concern towards prescription opioid misuse/dependence in the elderly. Thus, our study aimed at investigating the prevalence of previous and current prescribing opioid dependence among elderly medical inpatients recruited from a large German Hospital. METHODS: This cross-sectional study analysed a cohort of inpatients aged 65 years and older who were assessed with the help of a structured clinical interview (SCID-I). Levels of past/current opioid; benzodiazepines; hypnotics; and non-opioid analgesics’ dependence were assessed. RESULTS: Out of a total of 2,108 elderly inpatients admitted to the hospital over 6 months, some 400 fulfilled the inclusion criteria and agreed to participate to the survey. Some 43 (10.8%) subjects presented with a dependence on opioid analgesics; in 41 cases this was a current, and for 22 (51.2%) a de novo, condition. Addiction severity was considered mild and severe respectively in 65.1% and 11.6% of cases, with tilidine and oxycodone having been the most typically reported molecules. CONCLUSIONS: Further research is warranted, to better understand possible risk factors of prescription drug misuse/abuse/addiction in this vulnerable population. Clinicians should be updated and informed regarding both prescription medication misuse potential and safe prescribing practices in the elderly.