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        The e-psychonaut drugs’ psychopharmacology

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        Author
        Schifano, Fabrizio
        Chiappini, Stephania
        Corkery, John Martin
        Scherbaum, Norbert
        Guirguis, Amira
        Attention
        2299/24307
        Abstract
        The focus here was on the pharmacological and clinical pharmacological issues pertaining to the vast range of drugs (e.g. synthetic cannabimimetics, synthetic opioids, novel stimulants, novel psychedelics, PCP/ketamine-like compounds, prescribed medicinal compounds and popular psychotropic herbs/plants) discussed by Internet-based enthusiasts of new/novel psychoactive substances (NPS), ‘e-psychonauts’. Currently ongoing related in silico studies, followed by further in vitro and in vivo/preclinical studies, will hopefully provide important findings in terms of which molecules within each given NPS class may present with higher levels of receptor affinities, and hence clinical potency. Understanding the pharmacological characteristics/potency of those novel recreational molecules will hopefully help in predicting related NPS diffusion, morbidity and possible lethality data.
        Publication date
        2021-04-01
        Published in
        Current Opinion in Pharmacology
        Published version
        https://doi.org/10.1016/j.coph.2021.02.008
        License
        http://creativecommons.org/licenses/by-nc-nd/4.0/
        Other links
        http://hdl.handle.net/2299/24307
        Relations
        School of Life and Medical Sciences
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