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dc.contributor.authorTipduangta, Pratchaya
dc.contributor.authorBelton, Peter
dc.contributor.authorMcAuley, William
dc.contributor.authorQi, Sheng
dc.date.accessioned2021-05-07T23:09:45Z
dc.date.available2021-05-07T23:09:45Z
dc.date.issued2021-06-01
dc.identifier.citationTipduangta , P , Belton , P , McAuley , W & Qi , S 2021 , ' The use of polymer blends to improve stability and performance of electrospun solid dispersions: The role of miscibility and phase separation ' , International Journal of Pharmaceutics , vol. 602 . https://doi.org/10.1016/j.ijpharm.2021.120637
dc.identifier.issn0378-5173
dc.identifier.otherPURE: 25141565
dc.identifier.otherPURE UUID: 005830c2-5dce-4260-96c0-42ccde7d6f00
dc.identifier.otherScopus: 85105310200
dc.identifier.urihttp://hdl.handle.net/2299/24456
dc.description© 2021 Elsevier B.V. All rights reserved. This is the accepted manuscript version of an article which has been published in final form at https://doi.org/10.1016/j.ijpharm.2021.120637
dc.description.abstractSolid dispersion-based nanofiber formulations of poorly soluble drugs prepared by electrospinning (ES) with a water-soluble polymer, can offer significant improvements in drug dissolution for oral drug administration. However, when hygroscopic polymers, such as polyvinylpyrrolidone (PVP) are used, environmental moisture sorption can lead to poor physical stability on storage. This study investigated the use of polymer blends to modify PVP-based ES formulations of a model poorly soluble drug, fenofibrate (FF), to improve its physical stability without compromising dissolution enhancement. FF-PVP ES dispersions demonstrated clear dissolution enhancement, but poor storage stability against high humidity. Polymer blends of PVP with Eudragit E, Soluplus and hypromellose acetate succinate (HPMCAS), were selected because of the low intrinsic moisture sorption of these polymers. The drug-polymer and polymer-polymer miscibility study revealed that FF was more miscible with Eudragit E and Soluplus than with PVP and HPMCAS, and that PVP was more miscible with HPMCAS than Eudragit E and Soluplus. This led to different configurations of phase separation in the placebo and drug-loaded fibres. The in vitro drug release data confirmed that the use of PVP-Eudragit E retained the dissolution enhancement of the PVP formulation, whereas PVP-Soluplus reduced the drug release rate in comparison to FF-PVP formulations. The moisture sorption results confirmed that moisture uptake by the polymer blends was reduced, but formulation deformation occurred to phase-separated blend formulations. The data revealed the importance of miscibility and phase separation in understanding the physical stability of the ES fibre mats. The findings provide insight into the design of formulations that can provide dissolution enhancement balanced with improved storage stabilityen
dc.format.extent13
dc.language.isoeng
dc.relation.ispartofInternational Journal of Pharmaceutics
dc.titleThe use of polymer blends to improve stability and performance of electrospun solid dispersions: The role of miscibility and phase separationen
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionPharmaceutics
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.contributor.institutionSkin and Nail Group
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Clinical, Pharmaceutical and Biological Science
dc.description.statusPeer reviewed
dc.date.embargoedUntil2022-04-24
rioxxterms.versionAM
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.ijpharm.2021.120637
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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