dc.contributor.author | Zhao, Miao | |
dc.contributor.author | Leggett, Edward | |
dc.contributor.author | Bourke, Struan | |
dc.contributor.author | Poursanidou, Souzana | |
dc.contributor.author | Carter-Searjeant, Sadie | |
dc.contributor.author | Po, Steve | |
dc.contributor.author | Palma do Carmo, Marciano | |
dc.contributor.author | Dailey, Lea Ann | |
dc.contributor.author | Manning, Philip | |
dc.contributor.author | Ryan, Sean | |
dc.contributor.author | Urbano, Laura | |
dc.contributor.author | Green, Mark | |
dc.contributor.author | Rakovich, Aliaksandra | |
dc.date.accessioned | 2021-05-13T09:00:01Z | |
dc.date.available | 2021-05-13T09:00:01Z | |
dc.date.issued | 2021-05-12 | |
dc.identifier.citation | Zhao , M , Leggett , E , Bourke , S , Poursanidou , S , Carter-Searjeant , S , Po , S , Palma do Carmo , M , Dailey , L A , Manning , P , Ryan , S , Urbano , L , Green , M & Rakovich , A 2021 , ' Theranostic NIR-active Conjugated Polymer Nanoparticles ' , ACS Nano , vol. 15 , no. 5 , pp. 8790-8802 . https://doi.org/10.1021/acsnano.1c01257 | |
dc.identifier.issn | 1936-0851 | |
dc.identifier.other | ORCID: /0000-0001-9069-5122/work/93854016 | |
dc.identifier.other | ORCID: /0000-0001-8524-3359/work/93854105 | |
dc.identifier.uri | http://hdl.handle.net/2299/24484 | |
dc.description | © 2021 American Chemical Society. This is the accepted manuscript version of an article which has been published in final form at https://doi.org/10.1021/acsnano.1c01257 | |
dc.description.abstract | Conjugated polymer nanoparticles (CPNs) based on a common solar cell material (PTB7) have been prepared, and their potential in theranostic applications based on bioimaging and photosensitizing capabilities has been evaluated. The main absorption and emission bands of the prepared CPN particles both fell within the NIR-I (650-950 nm) transparency window, allowing facile and efficient implementation of our CPNs as bioimaging agents, as demonstrated in this work for A549 human lung cancer cell cultures. The prepared CPN samples were also shown to produce reactive oxygen species (ROS) upon photoexcitation in the near infrared or ultraviolet spectral regions, both in aqueous solutions and in HaCaT keratinocyte cell cultures. Importantly, we show that the photosensitizing ability of our CPNs was largely determined by the nature of the stabilizing shell: coating the CPNs with a pluronic F127 copolymer led to an improvement of photoinitiated ROS production, while using PSMA instead completely quenched said process. To best of our knowledge, this work is the first to demonstrate the modulation of the photosensitizing capability of CPNs via an appropriate selection of stabilizing material and one that opens a new gateway to the design of theranostic probes based on CPNs. | en |
dc.format.extent | 1036767 | |
dc.format.extent | 3399052 | |
dc.language.iso | eng | |
dc.relation.ispartof | ACS Nano | |
dc.subject | conjugated polymer nanoparticles | |
dc.subject | theranostic probe | |
dc.subject | NIR-I | |
dc.subject | reactive oxygen species | |
dc.subject | photodynamic therapy | |
dc.title | Theranostic NIR-active Conjugated Polymer Nanoparticles | en |
dc.contributor.institution | Department of Physics, Astronomy and Mathematics | |
dc.contributor.institution | Department of Clinical, Pharmaceutical and Biological Science | |
dc.contributor.institution | Centre for Research into Topical Drug Delivery and Toxicology | |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | School of Physics, Engineering & Computer Science | |
dc.contributor.institution | Centre for Astrophysics Research (CAR) | |
dc.description.status | Peer reviewed | |
dc.date.embargoedUntil | 2022-05-12 | |
rioxxterms.versionofrecord | 10.1021/acsnano.1c01257 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |