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dc.contributor.authorLegh-Land, Victoria
dc.contributor.authorHaddrell, Allen E.
dc.contributor.authorLewis, David
dc.contributor.authorMurnane, Darragh
dc.contributor.authorReid, Jonathan P.
dc.date.accessioned2021-06-24T12:00:03Z
dc.date.available2021-06-24T12:00:03Z
dc.date.issued2021-06-24
dc.identifier.citationLegh-Land , V , Haddrell , A E , Lewis , D , Murnane , D & Reid , J P 2021 , ' Water Uptake by Evaporating pMDI Aerosol Prior to Inhalation Affects Both Regional and Total Deposition in the Respiratory System ' , Pharmaceutics , vol. 13 , no. 7 , 941 . https://doi.org/10.3390/pharmaceutics13070941
dc.identifier.issn1999-4923
dc.identifier.urihttp://hdl.handle.net/2299/24602
dc.description© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)
dc.description.abstractAs pulmonary drug deposition is a function of aerosol particle size distribution, it is critical that the dynamics of particle formation and maturation in pMDI sprays in the interim between generation and inhalation are fully understood. This paper presents an approach to measure the evaporative and condensational fluxes of volatile components and water from and to solution pMDI droplets following generation using a novel technique referred to as the Single Particle Electrodynamic Lung (SPEL). In doing so, evaporating aerosol droplets are shown capable of acting as condensation nuclei for water. Indeed, we show that the rapid vaporisation of volatile components from a volatile droplet is directly correlated to the volume of water taken up by condensation. Furthermore, a significant volume of water is shown to condense on droplets of a model pMDI formulation (hydrofluoroalkane (HFA), ethanol and glycerol) during evaporative droplet ageing, displaying a dramatic shift from a core composition of a volatile species to that of predominantly water (non-volatile glycerol remained in this case). This yields a droplet with a water activity of 0.98 at the instance of inhalation. The implications of these results on regional and total pulmonary drug deposition are explored using the International Commission of Radiological Protection (ICRP) deposition model, with an integrated semi-analytical treatment of hygroscopic growth. Through this, droplets with water activity of 0.98 upon inhalation are shown to produce markedly different dose deposition profiles to those with lower water activities at the point of inspiration.en
dc.format.extent22
dc.format.extent34769684
dc.language.isoeng
dc.relation.ispartofPharmaceutics
dc.titleWater Uptake by Evaporating pMDI Aerosol Prior to Inhalation Affects Both Regional and Total Deposition in the Respiratory Systemen
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionPharmaceutics
dc.contributor.institutionAirway Group
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Clinical, Pharmaceutical and Biological Science
dc.description.statusPeer reviewed
rioxxterms.versionofrecord10.3390/pharmaceutics13070941
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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