dc.contributor.author | El-Taji, Omar | |
dc.contributor.author | Al-Mitwalli, Abdullah | |
dc.contributor.author | Malik, Farhan | |
dc.contributor.author | Agarwal, Samita | |
dc.contributor.author | Gogbashian, Andrew | |
dc.contributor.author | Hughes, Rob | |
dc.contributor.author | Vasdev, Nikhil | |
dc.contributor.author | Sharma, Anand | |
dc.date.accessioned | 2021-07-21T09:43:03Z | |
dc.date.available | 2021-07-21T09:43:03Z | |
dc.date.issued | 2021-06-01 | |
dc.identifier.citation | El-Taji , O , Al-Mitwalli , A , Malik , F , Agarwal , S , Gogbashian , A , Hughes , R , Vasdev , N & Sharma , A 2021 , ' Secondary Neoplasms of the Urinary Bladder-Clinical Management and Oncological Outcomes ' , Translational Andrology and Urology (TAU) , vol. 10 , no. 6 . https://doi.org/10.21037/tau-20-955 | |
dc.identifier.issn | 2223-4691 | |
dc.identifier.other | PURE: 24118297 | |
dc.identifier.other | PURE UUID: a58d4b6a-5daf-431e-9923-090b4ecd204d | |
dc.identifier.other | Scopus: 85108825682 | |
dc.identifier.other | PubMed: 34295729 | |
dc.identifier.uri | http://hdl.handle.net/2299/24870 | |
dc.description | © Translational Andrology and Urology. All rights reserved. This is an Open Access article distributed in accordance with the Creative Commons Attribution-Non Commercial-No Derivate 4.0 International License (CC BY-NC-ND 4.0), See: https://creativecommons.org/licenses/by-nc-nd/4.0/. | |
dc.description.abstract | Background: Secondary neoplasms of the bladder account for 4.5% of all bladder neoplasms however there is limited literature reporting management and survival. This is the largest single centre series presented in current literature with long term oncological follow up. Methods: This is a single institutional, retrospective cohort study of patients with a histological diagnosis of a secondary bladder neoplasm from January 2007 to December 2017 (n=40). Prognostic variables examined included age at diagnosis, histology, disease free survival and treatment. Kaplan-Meier analysis was used to calculate survival. We used multiple regression analysis to identify the most significant treatments for each population group in terms of their survival. Results: Twenty-one patients were male (53%) with a median age of 68 and 19 were female (47%) with a median age of 64. The most common secondary neoplasms and their median survival were prostate [12 patients (30%), 446 days], colorectal [9 patients (23%), 403 days], ovarian [5 patients (13%), 369 days], cervical [4 patients (10%), 148 days], breast [3 patients (8%), 241 days], lymphoma [3 patients (8%), 145 days], gastric [2 patients (5%), 66 days], and renal [2 patients (5%), 854 days]. Those receiving treatment following a secondary diagnosis demonstrated statistical significance in survival for colorectal (surgery P=0.013), prostate (radiotherapy P=0.0012 and hormonal therapy P=0.004) and ovarian cancer (chemotherapy P=0.00002). Conclusions: Prognosis and treatment depends upon the primary neoplasm. There is some survival benefit in well selected patients receiving treatment following a diagnosis of a bladder secondary. | en |
dc.format.extent | 10 | |
dc.language.iso | eng | |
dc.relation.ispartof | Translational Andrology and Urology (TAU) | |
dc.subject | Bladder cancer | |
dc.subject | Metastatic cancer | |
dc.subject | Secondary neoplasm | |
dc.subject | Survival | |
dc.subject | Reproductive Medicine | |
dc.subject | Urology | |
dc.title | Secondary Neoplasms of the Urinary Bladder-Clinical Management and Oncological Outcomes | en |
dc.contributor.institution | Department of Clinical, Pharmaceutical and Biological Science | |
dc.contributor.institution | Extracellular Vesicle Research Unit | |
dc.contributor.institution | Basic and Clinical Science Unit | |
dc.contributor.institution | Centre for Health Services and Clinical Research | |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.description.status | Peer reviewed | |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85108825682&partnerID=8YFLogxK | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | https://doi.org/10.21037/tau-20-955 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |