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dc.contributor.authorEl-Taji, Omar
dc.contributor.authorAl-Mitwalli, Abdullah
dc.contributor.authorMalik, Farhan
dc.contributor.authorAgarwal, Samita
dc.contributor.authorGogbashian, Andrew
dc.contributor.authorHughes, Rob
dc.contributor.authorVasdev, Nikhil
dc.contributor.authorSharma, Anand
dc.date.accessioned2021-07-21T09:43:03Z
dc.date.available2021-07-21T09:43:03Z
dc.date.issued2021-06-01
dc.identifier.citationEl-Taji , O , Al-Mitwalli , A , Malik , F , Agarwal , S , Gogbashian , A , Hughes , R , Vasdev , N & Sharma , A 2021 , ' Secondary Neoplasms of the Urinary Bladder-Clinical Management and Oncological Outcomes ' , Translational Andrology and Urology , vol. 10 , no. 6 . https://doi.org/10.21037/tau-20-955
dc.identifier.issn2223-4691
dc.identifier.otherPURE: 24118297
dc.identifier.otherPURE UUID: a58d4b6a-5daf-431e-9923-090b4ecd204d
dc.identifier.otherScopus: 85108825682
dc.identifier.otherPubMed: 34295729
dc.identifier.urihttp://hdl.handle.net/2299/24870
dc.description© Translational Andrology and Urology. All rights reserved. This is an Open Access article distributed in accordance with the Creative Commons Attribution-Non Commercial-No Derivate 4.0 International License (CC BY-NC-ND 4.0), See: https://creativecommons.org/licenses/by-nc-nd/4.0/.
dc.description.abstractBackground: Secondary neoplasms of the bladder account for 4.5% of all bladder neoplasms however there is limited literature reporting management and survival. This is the largest single centre series presented in current literature with long term oncological follow up. Methods: This is a single institutional, retrospective cohort study of patients with a histological diagnosis of a secondary bladder neoplasm from January 2007 to December 2017 (n=40). Prognostic variables examined included age at diagnosis, histology, disease free survival and treatment. Kaplan-Meier analysis was used to calculate survival. We used multiple regression analysis to identify the most significant treatments for each population group in terms of their survival. Results: Twenty-one patients were male (53%) with a median age of 68 and 19 were female (47%) with a median age of 64. The most common secondary neoplasms and their median survival were prostate [12 patients (30%), 446 days], colorectal [9 patients (23%), 403 days], ovarian [5 patients (13%), 369 days], cervical [4 patients (10%), 148 days], breast [3 patients (8%), 241 days], lymphoma [3 patients (8%), 145 days], gastric [2 patients (5%), 66 days], and renal [2 patients (5%), 854 days]. Those receiving treatment following a secondary diagnosis demonstrated statistical significance in survival for colorectal (surgery P=0.013), prostate (radiotherapy P=0.0012 and hormonal therapy P=0.004) and ovarian cancer (chemotherapy P=0.00002). Conclusions: Prognosis and treatment depends upon the primary neoplasm. There is some survival benefit in well selected patients receiving treatment following a diagnosis of a bladder secondary.en
dc.format.extent10
dc.language.isoeng
dc.relation.ispartofTranslational Andrology and Urology
dc.rightsOpen
dc.subjectBladder cancer
dc.subjectMetastatic cancer
dc.subjectSecondary neoplasm
dc.subjectSurvival
dc.subjectReproductive Medicine
dc.subjectUrology
dc.titleSecondary Neoplasms of the Urinary Bladder-Clinical Management and Oncological Outcomesen
dc.contributor.institutionDepartment of Clinical, Pharmaceutical and Biological Science
dc.contributor.institutionExtracellular Vesicle Research Unit
dc.contributor.institutionBasic and Clinical Science Unit
dc.contributor.institutionCentre for Health Services and Clinical Research
dc.contributor.institutionSchool of Life and Medical Sciences
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85108825682&partnerID=8YFLogxK
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2021-06-01
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.21037/tau-20-955
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


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