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dc.contributor.authorChan, Vinson Wai-Shun
dc.contributor.authorTan, Wei Shen
dc.contributor.authorAsif, Aqua
dc.contributor.authorNg, Alexander
dc.contributor.authorGbolahan, Olayinka
dc.contributor.authorDinneen, Eion
dc.contributor.authorTo, Wilson
dc.contributor.authorKadhim, Hassan
dc.contributor.authorPremchand, Melissa
dc.contributor.authorBurton, Oliver
dc.contributor.authorKoe, Jasmine Sze-Ern
dc.contributor.authorWang, Nicole
dc.contributor.authorLeow, Jeffrey
dc.contributor.authorGiannarini, Gianluca
dc.contributor.authorVasdev, Nikhil
dc.contributor.authorShariat, Shahrokh F
dc.contributor.authorEnikeev, Dmitry
dc.contributor.authorNg, Chi Fai
dc.contributor.authorTeoh, Jeremy Yeun-Chun
dc.date.accessioned2021-07-21T09:43:16Z
dc.date.available2021-07-21T09:43:16Z
dc.date.issued2021-06-30
dc.identifier.citationChan , V W-S , Tan , W S , Asif , A , Ng , A , Gbolahan , O , Dinneen , E , To , W , Kadhim , H , Premchand , M , Burton , O , Koe , J S-E , Wang , N , Leow , J , Giannarini , G , Vasdev , N , Shariat , S F , Enikeev , D , Ng , C F & Teoh , J Y-C 2021 , ' Effects of delayed radical prostatectomy and active surveillance on localised prostate cancer - A systematic review and meta-analysis ' , Cancers , vol. 13 , no. 13 , 3274 . https://doi.org/10.3390/cancers13133274
dc.identifier.issn2072-6694
dc.identifier.otherPURE: 25503033
dc.identifier.otherPURE UUID: 786c2dbf-8ef3-47eb-bc5f-ee782367dfc8
dc.identifier.otherScopus: 85108896568
dc.identifier.urihttp://hdl.handle.net/2299/24880
dc.description© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)
dc.description.abstractExternal factors, such as the coronavirus disease 2019 (COVID-19), can lead to cancellations and backlogs of cancer surgeries. The effects of these delays are unclear. This study summarised the evidence surrounding expectant management, delay radical prostatectomy (RP), and neoadjuvant hormone therapy (NHT) compared to immediate RP. MEDLINE and EMBASE was searched for randomised controlled trials (RCTs) and non-randomised controlled studies pertaining to the review question. Risks of biases (RoB) were evaluated using the RoB 2.0 tool and the Newcastle–Ottawa Scale. A total of 57 studies were included. Meta-analysis of four RCTs found overall survival and cancer-specific survival were significantly worsened amongst intermediate-risk patients undergoing active monitoring, observation, or watchful waiting but not in low- and high-risk patients. Evidence from 33 observational studies comparing delayed RP and immediate RP is contradictory. However, conservative estimates of delays over 5 months, 4 months, and 30 days for low-risk, intermediate-risk, and high-risk patients, respectively, have been associated with significantly worse pathological and oncological outcomes in individual studies. In 11 RCTs, a 3-month course of NHT has been shown to improve pathological outcomes in most patients, but its effect on oncological outcomes is apparently limiteden
dc.format.extent15
dc.language.isoeng
dc.relation.ispartofCancers
dc.rightsOpen
dc.titleEffects of delayed radical prostatectomy and active surveillance on localised prostate cancer - A systematic review and meta-analysisen
dc.contributor.institutionDepartment of Clinical, Pharmaceutical and Biological Science
dc.contributor.institutionExtracellular Vesicle Research Unit
dc.contributor.institutionBasic and Clinical Science Unit
dc.contributor.institutionCentre for Health Services and Clinical Research
dc.contributor.institutionSchool of Life and Medical Sciences
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2021-06-30
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.3390/cancers13133274
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


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