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        MRI-derived radiomics model for baseline prediction of prostate cancer progression on active surveillance

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        s41598_021_92341_6.pdf (PDF, 1Mb)
        Author
        Sushentsev, Nikita
        Rundo, Leonardo
        Blyuss, Oleg
        Gnanapragasam, Vincent J
        Sala, Evis
        Barrett, Tristan
        Attention
        2299/24923
        Abstract
        Nearly half of patients with prostate cancer (PCa) harbour low- or intermediate-risk disease considered suitable for active surveillance (AS). However, up to 44% of patients discontinue AS within the first five years, highlighting the unmet clinical need for robust baseline risk-stratification tools that enable timely and accurate prediction of tumour progression. In this proof-of-concept study, we sought to investigate the added value of MRI-derived radiomic features to standard-of-care clinical parameters for improving baseline prediction of PCa progression in AS patients. Tumour T2-weighted imaging (T2WI) and apparent diffusion coefficient radiomic features were extracted, with rigorous calibration and pre-processing methods applied to select the most robust features for predictive modelling. Following leave-one-out cross-validation, the addition of T2WI-derived radiomic features to clinical variables alone improved the area under the ROC curve for predicting progression from 0.61 (95% confidence interval [CI] 0.481-0.743) to 0.75 (95% CI 0.64-0.86). These exploratory findings demonstrate the potential benefit of MRI-derived radiomics to add incremental benefit to clinical data only models in the baseline prediction of PCa progression on AS, paving the way for future multicentre studies validating the proposed model and evaluating its impact on clinical outcomes.
        Publication date
        2021-06-21
        Published in
        Scientific Reports
        Published version
        https://doi.org/10.1038/s41598-021-92341-6
        Other links
        http://hdl.handle.net/2299/24923
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